Diabetes Care:你以为维持减肥就对2型糖尿病患者真正有益吗?

2016-07-23 fsy 译 MedSci原创

短期减肥可以改善心血管疾病(CVD)的危险因素。该研究试图确定维持减肥,或者反过来,恢复体重的长期影响。研究人员使用了来自糖尿病健康行动(Look AHEAD)的研究数据,Look AHEAD研究是一项随机试验,该试验在2型糖尿病患者中比较了强化生活方式干预(ILI)和条件控制的效果。ILI参与者根据体重变化模式分组:1)体重未下降(在第1和第4年时±3%);2)适度减肥(在第1和第4年时3-8%

短期减肥可以改善心血管疾病(CVD)的危险因素。该研究试图确定维持减肥,或者反过来,恢复体重的长期影响。

研究人员使用了来自糖尿病健康行动(Look AHEAD)的研究数据,Look AHEAD研究是一项随机试验,该试验在2型糖尿病患者中比较了强化生活方式干预(ILI)和条件控制的效果。ILI参与者根据体重变化模式分组:1)体重未下降(在第1和第4年时±3%);2)适度减肥(在第1和第4年时3-8%);3)较大程度的减肥(在第1和第4年时8-20%);4)中度减肥/完全恢复(在第1年时3-8%,在第4年时1/±3%);5)较大程度的减肥/完全恢复(在第1年时8-20%,在第4年时±3%);和6)较大程度的减肥/部分恢复(在第1年时8-20%,在第4年时3-8%),研究人员也对心血管疾病的风险因素变化进行了比较。

调整了基线差异和药物使用后,研究人员发现,在第1年和第4年时,体重下降程度越大的参与者,其HbA1c、收缩压、HDL胆固醇和甘油三酯水平就会有更大的改善(所有P≤0.02)。尽管维持了减肥的状况,HbA1c水平在第1年和第4年之间还是恶化了,只有在那些较大程度减肥的参与者的HbA1c水平维持在基线水平以下。减肥和体重恢复相对于没有减肥的人来说,研究人员并没有发现相互之间有负面联系。此外,那些在开始时减肥但在第4年体重完全恢复的人相对于在开始时没有减肥的人来说,HbA1c水平有了更大的改善。

尽管体重有恢复的可能性,但还是要鼓励那些2型糖尿病患者在患病初期去进行较大程度的减肥。

原始出处:

The Action for Health in Diabetes (Look AHEAD) Study Group,Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors,Diabetes Care,2016.7.23

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    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-13 舒心和人

    肥胖的患者体内脂肪含量多,内脏脂肪也不会少,会造成胰岛素抵抗,所以减肥利于健康

    0

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