AM J KIDNEY DIS:糖尿病前期血糖过高也会损害肾脏功能!

2015-12-31 chenshuo译 MedSci原创

以往的研究表明,糖尿病是肾脏疾病的主要危险因素之一。大约30%的1-型糖尿病患者和10-40%的2-型糖尿病患者会发展为肾衰竭。近日,由北挪威大学医院肾脏科Toralf Melsom博士和他的研究团队在美国肾脏病杂志期刊上发表的一项最新的研究成果表明,在糖尿病前期,高于正常的血糖水平也可能会导致肾脏损害。Toralf Melsom博士与他的团队成员发现,在很久以前已经有人开始试图寻找糖尿病与肾损伤

以往的研究表明,糖尿病是肾脏疾病的主要危险因素之一。大约30%的1-型糖尿病患者和10-40%的2-型糖尿病患者会发展为肾衰竭。


近日,由北挪威大学医院肾脏科Toralf Melsom博士和他的研究团队在美国肾脏病杂志期刊上发表的一项最新的研究成果表明,在糖尿病前期,高于正常的血糖水平也可能会导致肾脏损害。

Toralf Melsom博士与他的团队成员发现,在很久以前已经有人开始试图寻找糖尿病与肾损伤之间的关系,但是关于这方面的研究有众多不一致的结果。因此,Toralf Melsom博士决定从肾小球滤过率(GFR)使用评估方面着手研究,而不是仅通过测量肾小球滤过率(mGFR)。

肾小球滤过率是衡量肾功能试验的重要参数,较高的GFR标志着超滤-肾脏异常,可导致肾损伤。
在该项研究中,研究小组对1324名50-62岁的成年人进行测量肾小球滤过率、空腹血糖(FG)水平和糖化血红蛋白水平,以便更好的探讨糖尿病前期与肾损害是否有关。

根据2009的国际专家委员会的定义,FG水平为110-125 mg/dL(9 mmol/L)和/或HbA1c水平为6-6.4 %的,或按美国糖尿病协会的定义FG 水平为100-125 mg/dL(5.6-6.9 mmol/L)和/或HbA1c 5.7-6.4 %的,即可称为糖尿病前期。

研究结果发现,FG和糖化血红蛋白水平在糖尿病前期都是导致肾脏高滤过、尿中高蛋白的独立危险因素,这提示糖尿病前期可能是肾脏疾病发展的前兆。

针对该研究的成果,Toralf Melsom博士评论道:

“我们的研究表明,糖尿病前期的血糖水平升高可引起肾脏损伤。通过本研究,我们可以在糖尿病前期患者血糖升高时即开始进行早期干预预防慢性肾脏疾病(CKD)的发生。主治医生应该从此时开始改变患者的生活方式(如饮食和运动)来以防止疾病的发生,如糖尿病和肾脏疾病等。”

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    2016-01-02 milkshark

    当然

    0

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    2016-01-01 仁医06
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    2016-01-01 lu2996

    肾损害原因很多

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2012055, encodeId=a2a4201205526, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 17 02:43:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51088, encodeId=d58f51088c2, content=当然, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Sat Jan 02 06:28:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602954, encodeId=9755160295406, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jan 01 16:43:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50998, encodeId=8d5550998e8, content=肾损害原因很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50999, encodeId=08b25099906, content=高血糖引起肾损害临床不常见, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51000, encodeId=b75d5100073, content=所以还是要结合临床实际, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50997, encodeId=a89e5099ea9, content=这个结论过于肯定, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:23:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50752, encodeId=cfac50e5264, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151231/IMG5684A3A3C92AE9089.jpg, createdBy=c5e91675709, createdName=冰沸点点, createdTime=Thu Dec 31 12:27:00 CST 2015, time=2015-12-31, status=1, ipAttribution=)]
    2016-01-01 lu2996

    高血糖引起肾损害临床不常见

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2012055, encodeId=a2a4201205526, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 17 02:43:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51088, encodeId=d58f51088c2, content=当然, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Sat Jan 02 06:28:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602954, encodeId=9755160295406, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jan 01 16:43:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50998, encodeId=8d5550998e8, content=肾损害原因很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50999, encodeId=08b25099906, content=高血糖引起肾损害临床不常见, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51000, encodeId=b75d5100073, content=所以还是要结合临床实际, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50997, encodeId=a89e5099ea9, content=这个结论过于肯定, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:23:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50752, encodeId=cfac50e5264, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151231/IMG5684A3A3C92AE9089.jpg, createdBy=c5e91675709, createdName=冰沸点点, createdTime=Thu Dec 31 12:27:00 CST 2015, time=2015-12-31, status=1, ipAttribution=)]
    2016-01-01 lu2996

    所以还是要结合临床实际

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2012055, encodeId=a2a4201205526, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 17 02:43:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51088, encodeId=d58f51088c2, content=当然, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Sat Jan 02 06:28:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602954, encodeId=9755160295406, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jan 01 16:43:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50998, encodeId=8d5550998e8, content=肾损害原因很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50999, encodeId=08b25099906, content=高血糖引起肾损害临床不常见, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51000, encodeId=b75d5100073, content=所以还是要结合临床实际, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50997, encodeId=a89e5099ea9, content=这个结论过于肯定, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:23:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50752, encodeId=cfac50e5264, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151231/IMG5684A3A3C92AE9089.jpg, createdBy=c5e91675709, createdName=冰沸点点, createdTime=Thu Dec 31 12:27:00 CST 2015, time=2015-12-31, status=1, ipAttribution=)]
    2016-01-01 lu2996

    这个结论过于肯定

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2012055, encodeId=a2a4201205526, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 17 02:43:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51088, encodeId=d58f51088c2, content=当然, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Sat Jan 02 06:28:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602954, encodeId=9755160295406, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jan 01 16:43:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50998, encodeId=8d5550998e8, content=肾损害原因很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50999, encodeId=08b25099906, content=高血糖引起肾损害临床不常见, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51000, encodeId=b75d5100073, content=所以还是要结合临床实际, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:24:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50997, encodeId=a89e5099ea9, content=这个结论过于肯定, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 12:23:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50752, encodeId=cfac50e5264, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151231/IMG5684A3A3C92AE9089.jpg, createdBy=c5e91675709, createdName=冰沸点点, createdTime=Thu Dec 31 12:27:00 CST 2015, time=2015-12-31, status=1, ipAttribution=)]
    2015-12-31 冰沸点点

    有用

    0

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