J Gastroenterology:患有COVID-19的患者肝功能障碍与肝脏CT衰减值降低相关

2020-08-27 MedSci原创 MedSci原创

新冠肺炎患者中有三分之一的病人都有不同程度的肝功能异常。

        最近有报道称:新冠肺炎患者中有三分之一的病人都有不同程度的肝功能异常。香港中文大学医学院研究人员分析香港逾千名新冠患者情况后,发现约两成人有肝脏受损问题。这类患者病情恶化甚至死亡的风险,推算是其他患者的近8倍。

 

        最近一项评估患有COVID-19的患者肝功能障碍与肝脏CT衰减值降低相关性的文章在《Journal of Gastroenterology》获得了发表,文中报道所有纳入研究的35例患者在入院时均被诊断出患有轻度至中度的COVID-19,但在医院中的8例患者(22.9%)中,严重程度恶化为严重。肝细胞型肝损伤定义为血清AST和/或ALT水平升高至ULN的3倍以上的占5.7%,重度COVID-19患者的肝损伤患者百分比高于其余患者(P = 0.001)。患有肝功能障碍的患者肝脏CT衰减值明显较低,经过一段时间的治疗CT衰减值可以获得一定的提升。

 

        因此,我们可以得出这样一个结论,患有COVID-19的患者其肝功能障碍更容易出现且与CT衰减值有很大的关系。

 

原始出处:

Yoshihito Uchida. Et al. Significance of liver dysfunction associated with decreased hepatic CT attenuation values in Japanese patients with severe COVID-19. J Gastroenterology.2020.

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    2021-02-08 许安
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