Stroke:HbA1c升高与卒中患者脑白质病相关

2014-03-10 高晓方 译 医学论坛网

德国一项研究表明,在卒中患者中,糖化血红蛋白(HbA1c)水平升高与脑白质病(WMD)具有相关性。研究进一步提示血糖紊乱可能在WMD病理生理机制中发挥一定作用。论文于2月25日在线发表于《卒中》(Stroke)杂志。 此项研究共纳入512例首次急性缺血性卒中患者;受试者平均年龄68.5岁,女性占37.5%,中位NIHSS为3,中位Wahlund评分为4。受试者均在发病24小时内和第2天接

德国一项研究表明,在卒中患者中,糖化血红蛋白(HbA1c)水平升高与脑白质病(WMD)具有相关性。研究进一步提示血糖紊乱可能在WMD病理生理机制中发挥一定作用。论文于2月25日在线发表于《卒中》(Stroke)杂志。

此项研究共纳入512例首次急性缺血性卒中患者;受试者平均年龄68.5岁,女性占37.5%,中位NIHSS为3,中位Wahlund评分为4。受试者均在发病24小时内和第2天接受MRI检查。通过液体衰减反转恢复(FLAIR)序列MRI对WMD进行评分。评估住院期间的血管危险因素和实验室参数。

结果显示,460例(89.8%)患者伴有WMD。在单变量分析中,年龄、动脉高血压、估计肾小球滤过率降低、HbA1c水平、糖尿病和女性均与WMD存在具有相关性(P<0.05)。在多重回归分析中,年龄、动脉高血压和HbA1c水平升高仍与WMD程度具有独立相关性。

原始出处:

Rozanski M1, Richter TB, Grittner U, Endres M, Fiebach JB, Jungehulsing GJ.Elevated Levels of Hemoglobin A1c Are Associated With Cerebral White Matter Disease in Patients With Stroke.Stroke. 2014 Feb 25. 


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    2014-04-20 Smile2680
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