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耀斑反应性水凝胶治疗关节炎

2018-04-07 MedSci MedSci原创

关节炎耀斑水凝胶
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关节炎症状往往不可预测且常常突然恶化，这些事件使得炎症性关节炎（包括类风湿性关节炎和银屑病关节炎）的处理对患者和医生都极具挑战性

关节炎症状往往不可预测且常常突然恶化，这些事件使得炎症性关节炎（包括类风湿性关节炎和银屑病关节炎）的处理对患者和医生都极具挑战性。但伯明翰妇女医院（BWH）的研究人员发现，耀斑可能也是改善患者治疗方案的重要机会。在实验室进行的研究中，BWH生物工程师开发了一种水凝胶，这是一种柔韧的材料，可以装载关节炎药物并局部注入发炎关节。水凝胶并非以稳定的速率持续输送药物，而是设计用来对疾病的耀斑活动增加作出反应，即当症状恶化时释放药物。该团队的研究结果本周在Nature Communications上发表，研究人员正在努力将这一技术推向临床。

BWH的生物工程师兼首席研究员Jeff Karp博士说，“关节炎代表了巨大的未满足的临床需求，尽管已经开发出新的治疗方法，但许多方案具有全身毒性。我们希望设计一种高效的输送系统，可以输送药物并释放药物来应对炎症”。新的耀斑响应性水凝胶由三甘油单硬脂酸酯（TG-18）制成，该化合物是美国食品和药物管理局认定的“公认安全”化合物的一种， TG-18是一种能够自组装的分子，意味着它可以形成包含纤维的凝胶状结构。在本研究中，TG-18水凝胶装载了曲安奈德（TA），但TG-18可能装载多种类型的抗炎化合物。


原始出处：

https://www.europeanpharmaceuticalreview.com/news/74244/flare-responsive-hydrogel-arthritis/

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    2018-09-24 12499e01m47暂无昵称

    #反应性#

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    2018-04-09 lmm397

    #关节炎#

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    2018-04-09 tastas

    #水凝胶#

    0

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    2018-04-09 lishizhe

    #凝胶#

    0

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