Stroke:中年妇女更年期潮热和颈动脉内膜中层厚度的关系

2016-11-13 haofan MedSci原创

报告每日潮热的妇女中,频繁的潮热可能比心血管疾病的危险因素和雌激素提供了更多的女性血管状况的信息。频繁的潮热可能标志着中年妇女脆弱的血管表型。

女性更年期及其对相关的心血管疾病的发生发展的作用一直是研究的热点,大多数中年妇女在绝经时都经历过更年期潮热,新的研究数据将更年期潮热作为心血管疾病的风险指标。近日,卒中领域权威杂志stroke上发表了一篇来自美国匹兹堡大学医学院精神科的Rebecca C. Thurston医生及其团队的研究文章,旨在明确更年期潮热(通过最先进的生理方法测得)是否与亚临床动脉粥样硬化(经颈动脉超声评估)存在相关性,而且研究者考虑了心血管疾病的危险因素和雌激素浓度在这种相关性中的作用。

该研究共纳入了295名不吸烟并且无临床心血管疾病的女性作为研究对象,研究人员对其进行了动态生理潮热的评估、抽血,以及超声检测颈动脉内膜中层厚度和斑块情况。研究者在控制心血管危险因素和雌二醇水平的回归模型中评估了潮热和亚临床动脉粥样硬化之间的相关性。

研究者发现在报告每日潮热的妇女中,频繁的生理潮热与较厚的颈动脉内膜中层厚度(每增加一次潮热:β[SE]=0.004[0.001];P=0.0001;报告的潮热次数:β[SE]=0.008[0.002];P=0.002)和较多的斑块(如每增加一次潮热,相对于无斑块者,斑块指数≥2的比值比[95%可信区间]=1.07[1.003–1.14];P=0.04)之间存在相关性;而它们之间的这种相关性与心血管疾病危险因素或雌二醇无关。在报告有潮热的妇女中,相比于大多数心血管疾病的危险因素,潮热引起内膜中层厚度更大的变化。

由此可见,报告每日潮热的妇女中,频繁的潮热可能比心血管疾病的危险因素和雌激素提供了更多的女性血管状况的信息。频繁的潮热可能标志着中年妇女脆弱的血管表型。

原始出处:

 
Rebecca C. Thurston, et al. Menopausal Hot Flashes and Carotid Intima Media Thickness Among Midlife Women. Stroke.2016.November 10, 2016

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