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大腿肌无力可预测女性膝骨关节炎

2017-03-08 Frontline Medical News Frontline Medical Ne

大腿肌无力
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根据一项最新的病例对照研究结果，与男性相比，大腿肌无力是女性膝骨关节炎的更强危险因素，这可能由于较高的体质指数(BMI)对女性大腿肌肉力量的影响更大。这项研究结果已于2月8日在《Arthritis Care & Research》杂志上在线发表(doi： 10.1002/acr.23182)。奥地利Paracelsus医科大学的Adam Culvenor医师及其同事在这项名为骨关节炎倡议的

根据一项最新的病例对照研究结果，与男性相比，大腿肌无力是女性膝骨关节炎的更强危险因素，这可能由于较高的体质指数(BMI)对女性大腿肌肉力量的影响更大。这项研究结果已于2月8日在《Arthritis Care & Research》杂志上在线发表(doi： 10.1002/acr.23182)。

奥地利Paracelsus医科大学的Adam Culvenor医师及其同事在这项名为骨关节炎倡议的多中心研究中招募了161例影像学膝骨关节炎患者和186例基线时无关节炎的对照者，随访4年以上，研究目前仍在进行。约60%的患者和对照者为女性。研究人员对受试者的膝屈肌群(股后肌群)和伸肌群(股四头肌)进行轴向MRI扫描，以计算特定的肌肉力量。

研究人员发现，这些特定区域的肌肉力量较低会显着增加女性罹患膝骨关节炎的风险，膝屈肌群比值比为1.47(95% CI：1.10～1.96)，伸肌群比值比为1.41(95% CI：1.06～1.89)。这一相关性在男性中不具显着性，并且在校正了较高的BMI后，这一相关性在女性中也不再具有显着性。在女性中，特定肌肉力量较低与较高的BMI相关(r=–0.29，P<0.001)，而在男性中不存在这一相关性。

Culvenor医师分析指出，BMI较高(可能由肌肉内脂肪较多所致)的女性(而非男性)特定肌肉力量较低，这或许可以解释为何均存在肌肉力量缺陷的男性和女性，其膝骨关节炎的发生率不同。“男性和女性大腿肌肉对BMI变化的反应存在差异，BMI较高的男性显然具有更多的收缩组织(和更大的力量)，而BMI较高的女性显然具有更多的非收缩(脂肪)组织。”

美国国立卫生研究院和某药企联合会共同赞助了这项研究。研究结果的分析工作还获得了Paracelsus医科大学和欧盟第七框架计划的资助。7名共同作者中有3名披露了利益关系，包括与Chondrometrics GmbH(一家提供MRI分析服务的公司)及其他公司的雇佣关系，而其余4名无利益冲突披露。

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    2017-10-18 zhangpaul93

    #膝骨#

    0

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    2017-06-02 lisa438

    #骨关节#

    0

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    2017-04-11 春暖花开8785

    物理因素在骨性关节炎发病及进展中的作用！

    0

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    2017-03-10 lmm397

    #关节炎#

    0

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    2017-03-10 zlawrance

    #膝骨关节炎#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1747029, encodeId=5d6e1e4702963, content=<a href='/topic/show?id=495385896b5' target=_blank style='color:#2F92EE;'>#膝骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85896, encryptionId=495385896b5, topicName=膝骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Wed Oct 18 20:56:00 CST 2017, time=2017-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026523, encodeId=0fab20265238e, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Fri Jun 02 21:56:00 CST 2017, time=2017-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186672, encodeId=83de1866e20d, content=物理因素在骨性关节炎发病及进展中的作用！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kym1A9qicflExZYSdibSZBHDyicKZZj37w4jR44fPa9DI3mVLObHAxzntpTAbwxeHvviclcw8coNrDge/0, createdBy=6dc22001775, createdName=春暖花开8785, createdTime=Tue Apr 11 11:57:41 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265379, encodeId=b19612653e929, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Fri Mar 10 12:56:00 CST 2017, time=2017-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269239, encodeId=00e51269239a0, content=<a href='/topic/show?id=59088589e97' target=_blank style='color:#2F92EE;'>#膝骨关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85897, encryptionId=59088589e97, topicName=膝骨关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Fri Mar 10 12:56:00 CST 2017, time=2017-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436648, encodeId=1da21436648c1, content=<a href='/topic/show?id=e7c18092578' target=_blank style='color:#2F92EE;'>#肌无力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80925, encryptionId=e7c18092578, topicName=肌无力)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Mar 10 12:56:00 CST 2017, time=2017-03-10, status=1, ipAttribution=)]
    2017-03-10 zhouqu_8

    #肌无力#

    0