体重高不高免疫有话说

2016-09-12 Donal O Shea 《细胞—新陈代谢》

一个

一个爱尔兰、美国和加拿大联合研究小组发现，免疫系统对机体调节体重的能力有高达40%的“决定权”。相关成果近日发表在《细胞—新陈代谢》期刊。

该研究通讯作者、圣文森特大学附属医院内分泌学家Donal O Shea说：“我们知道，一旦体重增加，对大多数人来说，减肥是非常困难的。很多人简单地认为，少吃点，多运动，体重就会降下来。但事实并非如此。人体有非常强大的反应防止体重减轻。现在我们知道这种强大的抵抗反应与免疫系统相关。”

通常，免疫系统负责对抗感染和疾病。然而，从进化的角度来说，突然或快速的体重减少可能是一个更直接的威胁。哈佛医学院的助理教授Lydia Lynch解释道：“我们发现一种称为iNKT细胞的常见免疫细胞在这一过程中扮演了重要的角色。”

脂肪细胞在iNKT细胞的帮助下产生了一种称为成纤维细胞生长因子-21的蛋白（FGF-21）。FGF-21能触发人体代谢或者将白色脂肪转变为更为健康的棕色脂肪。这种白色脂肪棕色化的过程需要使用大量能量，从而导致代谢率增加以及体重降低。

研究人员指出，研究发现，肥胖的人免疫系统相对“迟钝”，含有的iNKT细胞数量也较低。这种情况下，机体不会产生FGF-21，从而阻止了白色脂肪转变为棕色脂肪。因此，如果刺激身体产生iNKT细胞，就能够增加FGF-21的数量，从而增强代谢率和体重降低。

Brendan Quinn是一名健身教练，但在患上免疫系统紊乱后，开始变得肥胖。尽管他的饮食和运动水平都没有变，但在3-4年内，体重从76 kg增长到了120 kg。

“我对自己的饮食和锻炼要求一直非常严格。理论上，我体重应该会降低，但事实上并没有。”他说。当OShea联系他时，Quinn非常乐于尝试这种新方法：让免疫系统更好地工作。这一方法很快产生了效果。Quinn在前5周内减了12 kg ，5个月以来，共减了23 kg。

研究人员称，这是肥胖领域的一个重要突破，为调节体重（如治疗肥胖）指明了新方向。

原始出处

Lydia Lynch1, 2, 8, , , Andrew E. Hogan3, Danielle Duquette1, Chantel Lester1, Alexander Banks2, Katherine LeClair4, David E. Cohen4, Abhisek Ghosh1, Bing Lu1, Michelle Corrigan3, Darko Stevanovic5, Eleftheria Maratos-Flier5, Daniel J. Drucker6, Donal O’Shea3, 7,Michael Brenner1.iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy.cell metabolism.2016

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2016-09-14 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

43 0
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2016-09-14 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

53 0
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2016-09-13 和小尚

这个研究成果将是治疗肥胖病的一个新阶段！

44 0
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2016-09-13 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

48 0
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2016-09-13 1dee1b88m43(暂无匿称)

讲的非常好！

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encodeId=97cc1243e79e, content=别人的研究都这么有意思，好酷, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/17/3872cad7a53dc9dcbd08202fb6313cf4.jpg, createdBy=2cb71609450, createdName=KO229256262, createdTime=Tue Sep 13 09:04:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
2016-09-13 doctorJiangchao

继续关注

28 0
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2016-09-13 doctorJiangchao

继续学习

28 0
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2016-09-13 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

26 0
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2016-09-13 1dd8c52fm63(暂无匿称)

我要减肥！

20 0
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2016-09-13 KO229256262

别人的研究都这么有意思，好酷

31 0

免疫学大牛！清华大学祁海教授发表多篇Nature、Science

导语：8月30日，清华大学祁海（Hai Qi）教授在Nature Reviews Immunology杂志（影响因子39.416）上发表了题为“T follicular helper cells in space-time”的综述文章。事实上，这位“大牛”8月初也在Nature上发表了一项重要的免疫学成果，揭示了一种新的CD8＋T细胞亚群。小编注意到，近几年，祁海教授在Nature、Science等杂志上发表了多项研究成果。现在，就跟随小编来一起了解下这位“大牛”究竟积累了哪些成果吧。

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