Diabetic Med:华南地区超重和肥胖Ⅱ型糖尿病患者非酒精性脂肪性肝病的患病率和风险增加

2017-07-05 MedSci MedSci原创

近日,国际杂志 《Diabetic medicine》上在线发表一项关于华南地区超重和肥胖Ⅱ型糖尿病患者非酒精性脂肪性肝病的患病率和风险增加的研究,目的在于调查超重和肥胖Ⅱ型糖尿病患者非酒精性脂肪性肝病的患病率和危险因素。

近日,国际杂志 《Diabetic medicine》上在线发表一项关于华南地区超重和肥胖Ⅱ型糖尿病患者非酒精性脂肪性肝病的患病率和风险增加的研究,目的在于调查超重和肥胖Ⅱ型糖尿病患者非酒精性脂肪性肝病的患病率和危险因素。

研究人员收集来自中国广东省21个城市60家医院从2011820123月进行人体测量,生化检查和腹部超声且BMI24Kg/m22糖尿病门诊患者数据。

研究包括3861名患者(1860名男性),平均± sd(范围)年龄为58.91±13.0618-90)岁。175145.4%)例患者发现非酒精性脂肪性肝病,男性患病率明显高于女性(48.0vs 42.9%)。非酒精性脂肪肝疾病的患病率的峰值是在患者的BMI34-35 Kg/m2,这些患者甘油三酯/ HDL胆固醇比为 5.5-6.0的,男性年龄<30岁,女性年龄40-50岁。使用BARDBMI,天冬氨酸氨基转移酶/丙氨酸氨基转移酶比率,糖尿病)评分系统评估,所有患者的晚期纤维化患病率为80.52%,女性患病率高于男性(86.52vs 74.16%)。多元逻辑回归分析表明,非酒精性脂肪、BMI2-h餐后血糖是非酒精性脂肪肝疾病独立的危险因素,而心率和女性性别则是保护因素。

研究表明,华南地区超重和肥胖2型糖尿病患者非酒精性脂肪性肝病患病率高。多发性代谢紊乱与超重和肥胖型2型糖尿病患者的非酒精性脂肪性肝病显著相关。

原始出处:

M. Yi, R.-P. Chen, R. Yang,et al. Increased prevalence and risk of non-alcoholic fatty liver disease in overweight and obese patients with Type 2 diabetes in South China

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1637904, encodeId=1e38163e904a9, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 23 13:35:00 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760095, encodeId=3fcc1e6009531, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  6. 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encodeId=80da1250485b8, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Jul 07 14:35:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474243, encodeId=8af514e4243d7, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jul 07 14:35:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607788, encodeId=d11b160e78848, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jul 07 14:35:00 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2018-01-15 qjddjq
  7. 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