J Hypertens:主动脉根部直径可能与心血管事件密切关联(PAMELA研究)

2014-07-19 MedSci MedSci原创

最新一项来自于意大利米兰Milano-Bicocca大学研究者发现主动脉根部直径( aortic root diameter,ARD)(通过超声心动图)与心血管并发症和致死性相关。这项研究共纳入1860位受试者(平均年龄 50 ± 14, 50.6% men),通过实验室检查,血压测定,超声心动图等测量。研究共随访148个月,共观察到137例非致死性和致死性心血管事件。校正年龄,性别,血压以及空腹

最新一项来自于意大利米兰Milano-Bicocca大学研究者发现主动脉根部直径( aortic root diameter,ARD)(通过超声心动图)与心血管并发症和致死性相关。

这项研究共纳入1860位受试者(平均年龄 50 ± 14, 50.6% men),通过实验室检查,血压测定,超声心动图等测量。

研究共随访148个月,共观察到137例非致死性和致死性心血管事件。校正年龄,性别,血压以及空腹血糖和总胆固醇,吸烟状态,此前心血管疾病以及是否使用降压药物后发现,ARD/身高与心血管事件密切关联(每升高一个单位HR上升2.62, 95%CI: 1.19-5.75, p=0.01),但与绝对ARD无关(HR:1.44, 95%CI:0.89-2.39, P = 0.13),也不与ARD/体表面积有关(HR:2.09, 95% CI 0.96-4.55, P = 0.06)。另外,左室肥厚,AR扩张也是重要的心血管预后的预测因素,比单纯左室肥厚更明显。

上述结果表明ARD指数(ARD/身高比),可能是非致死性和致死性心梗的关键风险因素。

原始出处:

Cuspidi C, Facchetti R, Bombelli M, Re A, Cairoa M, Sala C, Tadic M, Grassi G, Mancia G.Aortic root diameter and risk of cardiovascular events in a general population: data from the PAMELA study.J Hypertens. 2014 Jul 2.

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    2014-09-13 feather89
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    2014-07-24 qingfengqishi5

    研究新方向!

    0

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