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Kidney Int：重组α-Klotho有望成为预防和治疗急性向慢性肾脏疾病发展及尿毒症性心肌病的新选择

2017-05-23 lishiting MedSci原创

α-KlothoCKDAKI预防治疗
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α-Klotho高表达于肾脏，它的胞外区域可以被切断并释放到循环中。慢性肾脏疾病（CKD）的一个特征即为α-Klotho缺失，它对众多脏器表现出多重的负面系统效应，包括心血管系统。

α-Klotho高表达于肾脏，它的胞外区域可以被切断并释放到循环中。慢性肾脏疾病（CKD）的一个特征即为α-Klotho缺失，它对众多脏器表现出多重的负面系统效应，包括心血管系统。

因为急性肾脏损伤（AKI）大幅度增加CKD进展的风险，学者们一直致力于研究α-Klotho作为预防和治疗手段对AKI后向CKD的进展以及心血管疾病的影响。其中，形成了CKD预防方案：在发生缺血再灌注损伤诱发的AKI后，损伤后第1天至第4天持续重组α-Klotho或载体的早期给药；也形成了CKD治疗方案：在单侧肾脏切除伴随对侧缺血再灌注损伤造成的CKD模型中，损伤后4周开始α-Klotho给药，并持续12周。预防方案防止AKI向CKD的进展，并在AKI后的模型中保护心脏避免心脏重塑。外源性α-Klotho疗法的一个重要作用就在于持久恢复内源性α-Klotho水平直到停止外源性α-Klotho治疗。而治疗方案也有效改善CKD中的肾脏功能以及减弱心脏重塑，尽管相关指标没有完全恢复到正常水平。另外，在预先未患肾脏疾病的情况下，给予α-Klotho也减弱了高磷酸盐饮食诱发的肾脏和心脏纤维化，改善肾脏和心脏功能。

结论：重组α-Klotho蛋白是安全有效的，有望成为预防和延缓AKI向CKD的进展以及尿毒症性心肌病的新选择。

原始出处：

Hu MC， Shi M， et al. Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy. Kidney Int. 2017 May；91(5)：1104-1114. doi： 10.1016/j.kint.2016.10.034.

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    2017-06-06 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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    2017-05-25 惠映实验室

    又有新的发展，真好

    0

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    2017-05-25 lou.minghong

    学习

    0

  4. 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createdName=惠映实验室, createdTime=Thu May 25 23:46:47 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202409, encodeId=431320240908, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Thu May 25 12:39:27 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290397, encodeId=fdf7129039e3e, content=<a href='/topic/show?id=facb4e432e4' target=_blank style='color:#2F92EE;'>#尿毒症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47432, encryptionId=facb4e432e4, topicName=尿毒症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Thu May 25 10:29:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407818, encodeId=55c3140e81868, content=<a href='/topic/show?id=ab471053548' target=_blank style='color:#2F92EE;'>#Klotho#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10535, encryptionId=ab471053548, topicName=Klotho)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu May 25 10:29:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603045, encodeId=ac88160304535, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, 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    2017-05-25 tcm99hq

    #尿毒症#

    0

  5. 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    2017-05-25 仁者大医

    #Klotho#

    0

  6. 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    2017-05-25 gwc389

    #kidney#

    0

  7. 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href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu May 25 10:29:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201914, encodeId=43fb201914b3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed May 24 07:28:25 CST 2017, time=2017-05-24, status=1, ipAttribution=), 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    2017-05-25 12498b08m96暂无昵称

    #慢性肾脏#

    0

  8. 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    2017-05-25 爆笑小医

    #肌病#

    0

  9. 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href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu May 25 10:29:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201914, encodeId=43fb201914b3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed May 24 07:28:25 CST 2017, time=2017-05-24, status=1, ipAttribution=), 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    2017-05-24 Jackie Li

    学习

    0

  10. 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href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu May 25 10:29:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201914, encodeId=43fb201914b3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed May 24 07:28:25 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201878, encodeId=cd5d2018e85f, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed May 24 06:44:10 CST 2017, time=2017-05-24, status=1, ipAttribution=)]
    2017-05-24 飛歌

    学习了很有用

    0

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