Neurology:抑郁与认知和脑老化标志相关性研究

2018-05-14 zhangfan MedSci原创

研究认为,对于非中风老年人群,抑郁症状与情景记忆能力、脑体积以及静息性梗死风险相关

近日研究人员考察了老年人群严重的抑郁症状与特定领域的认知表现、认知变化、脑萎缩和亚临床血管病MRI标记之间的关系。

研究分析了北曼哈顿研究数据,参与者多数为加勒比西班牙裔、无中风症状,年龄偏大。1111人接受了基线抑郁症状、MRI标记物及认知功能评估。抑郁评分≥16分群体定义为重症抑郁患者,采用多元线性和逻辑回归模型考察重症抑郁与认知异常的相关性。

基线时,22%的参与者确诊为重度抑郁人群。调整社会人口学、血管危险因素、行为和抗抑郁药物等变量后,抑郁程度与事件记忆能力下降相关。重症抑郁与脑实质容积减少和脑梗死几率增加相关,但与白质高强度体积、海马体积或平均5年的认知变化不相关。

研究认为,对于非中风老年人群,抑郁症状与情景记忆能力、脑体积以及静息性梗死风险相关。

原始出处:


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    2018-07-02 yinhl1978
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    2018-05-15 baihao215

    depression的危害逐渐被认识

    0

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    2018-05-14 虈亣靌

    学习了受益匪浅

    0

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    2018-05-14 医者仁心5538

    学习了

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