Br J Surg:胃十二指肠穿孔手术治疗后,再次手术的危险因素研究

2016-11-09 MedSci MedSci原创

胃十二指肠溃疡穿孔的死亡率很高。手术修复后需要再次干预,与更差的结局有关。但关于再次手术危险因素的知识是有限的。研究目的是,识别与胃十二指肠溃疡穿孔后再次手术的预后危险因素。所有患者在2003到2014年丹麦进行胃十二指肠溃疡穿孔的手术治疗。共有4086例患者行手术治疗胃十二指肠溃疡穿孔。年龄中位数为71·1(i.q.r. 59·6-81·0)岁,整体90天的死亡率为30·8%(1258/4086

胃十二指肠溃疡穿孔的死亡率很高。手术修复后需要再次干预,与更差的结局有关。但关于再次手术危险因素的知识是有限的。

研究目的是,识别与胃十二指肠溃疡穿孔后再次手术的预后危险因素。

所有患者在2003到2014年丹麦进行胃十二指肠溃疡穿孔的手术治疗。共有4086例患者行手术治疗胃十二指肠溃疡穿孔。年龄中位数为71.1(IQR,59.6-81.0)岁,整体90天的死亡率为30.8%(1258/4086)。

再次手术的危险因素有:男性(调整后的危险比(HR)1.46, 95% c.i. 1.20 to 1.78)、院内穿孔(调整后的HR 1.36, 1.11 to 1.68)、高BMI(调整后的HR 1.49, 1.10 to 2.01)、高ASA分级(调整后的HR 1.54, 1.23 to 1.94)、入院时休克(调整后的HR 1.40, 1.13 to 1.74)、手术延迟(调整后的HR 1.07, 1.02 to 1.14)、其他共病(调整后的HR 1.24, 1.02 to 1.51)。

与手术风险降低有关的因素:入院前使用类固醇(调整后的HR 0.59, 0.41 to 0.84)、年龄70岁以上(调整后的HR 0.72, 0.59 to 0.89)。

肥胖男性有并存疾病,以及疾病的严重程度高,其胃十二指肠穿孔手术后的再次手术风险增加。

原始出处:


Hasselager RB1, Lohse N2,3, Duch P4, Møller MH5.Risk factors for reintervention after surgery for perforated gastroduodenal ulcer.Br J Surg. 2016 Nov;103(12):1676-1682. 


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    2016-11-15 ylzr123

    与手术风险降低有关的因素:入院前使用类固醇(调整后的HR0.59,0.41to0.84)、年龄70岁以上。肥胖男性有并存疾病,以及疾病的严重程度高,其胃十二指肠穿孔手术后的再次手术风险增加。

    0

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    2016-11-10 ylzr123

    手术风险降低有关的因素有入院前使用类固醇及年龄70岁以上;肥胖男性有并存疾病,以及疾病的严重程度高,其胃十二指肠穿孔手术后的再次手术风险增加。

    0

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