Stroke:磁共振DWI和PWI加权成像可预测最终梗塞体积(DEFUSE 2研究)

2013-03-09 高晓方 医学论坛网

  美国学者的一项研究表明,基线弥散加权成像(DWI)和早期随访灌注加权成像(PWI)可对卒中患者介入治疗后最终梗塞体积做出合理预测。论文发表于《卒中》[Stroke 2013, 44(3):681]。   此项研究为DEFUSE2的亚组研究,并纳入了在3个时间点接受MRI扫描的所有患者。利用RAPID软件程序确定基线DMI和早期随访PWI病变体积。通过5天液体衰减反转恢复(

  美国学者的一项研究表明,基线弥散加权成像(DWI)和早期随访灌注加权成像(PWI)可对卒中患者介入治疗后最终梗塞体积做出合理预测。论文发表于《卒中》[Stroke 2013, 44(3):681]。   此项研究为DEFUSE2的亚组研究,并纳入了在3个时间点接受MRI扫描的所有患者。利用RAPID软件程序确定基线DMI和早期随访PWI病变体积。通过5天液体衰减反转恢复(FLAIR)评估最终梗塞体积,并对水肿加以校正。以基线和早期随访MRI之间PWI病变体积缩小定义再灌注。对DWI和PWI体积与最终梗塞体积的相关性加以评估。   结果显示,共有73例患者符合纳入标准。在再灌注>90%的26例患者中,早期DWI体积与最终梗塞体积具有高度相关性(P<0.001)。在再灌注<10%的9例患者中,基线PWI体积与最终梗塞体积具有高度相关性(P=0.002)。在整体患者中,基线DWI与早期随访PWI组合与最终梗塞体积高度相关(P<0.001)。观察和预测最终梗塞体积的中位绝对差异为15 mL。 原始链接: Wheeler HM, Mlyn

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2049954, encodeId=ca2e204995450, content=<a href='/topic/show?id=7620149192b' target=_blank style='color:#2F92EE;'>#PWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14919, encryptionId=7620149192b, topicName=PWI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Wed Jul 24 02:06:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784149, encodeId=d0201e84149cb, content=<a href='/topic/show?id=9aa3582177' target=_blank style='color:#2F92EE;'>#DEFUSE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5821, encryptionId=9aa3582177, topicName=DEFUSE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ca5383, createdName=bbjsj_1979, createdTime=Sat Jul 20 15:06:00 CST 2013, time=2013-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278699, encodeId=609912e869914, content=<a href='/topic/show?id=c3026349f4' target=_blank style='color:#2F92EE;'>#DWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6349, encryptionId=c3026349f4, topicName=DWI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Mon Mar 11 14:06:00 CST 2013, time=2013-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341516, encodeId=aecc13415161d, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Mar 11 14:06:00 CST 2013, time=2013-03-11, status=1, ipAttribution=)]
    2013-07-24 仁医06
  2. [GetPortalCommentsPageByObjectIdResponse(id=2049954, encodeId=ca2e204995450, content=<a href='/topic/show?id=7620149192b' target=_blank style='color:#2F92EE;'>#PWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14919, encryptionId=7620149192b, topicName=PWI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Wed Jul 24 02:06:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784149, encodeId=d0201e84149cb, content=<a href='/topic/show?id=9aa3582177' target=_blank style='color:#2F92EE;'>#DEFUSE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5821, encryptionId=9aa3582177, topicName=DEFUSE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ca5383, createdName=bbjsj_1979, createdTime=Sat Jul 20 15:06:00 CST 2013, time=2013-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278699, encodeId=609912e869914, content=<a href='/topic/show?id=c3026349f4' target=_blank style='color:#2F92EE;'>#DWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6349, encryptionId=c3026349f4, topicName=DWI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Mon Mar 11 14:06:00 CST 2013, time=2013-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341516, encodeId=aecc13415161d, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Mar 11 14:06:00 CST 2013, time=2013-03-11, status=1, ipAttribution=)]
    2013-07-20 bbjsj_1979
  3. [GetPortalCommentsPageByObjectIdResponse(id=2049954, encodeId=ca2e204995450, content=<a href='/topic/show?id=7620149192b' target=_blank style='color:#2F92EE;'>#PWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14919, encryptionId=7620149192b, topicName=PWI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Wed Jul 24 02:06:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784149, encodeId=d0201e84149cb, content=<a href='/topic/show?id=9aa3582177' target=_blank style='color:#2F92EE;'>#DEFUSE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5821, encryptionId=9aa3582177, topicName=DEFUSE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ca5383, createdName=bbjsj_1979, createdTime=Sat Jul 20 15:06:00 CST 2013, time=2013-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278699, encodeId=609912e869914, content=<a href='/topic/show?id=c3026349f4' target=_blank style='color:#2F92EE;'>#DWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6349, encryptionId=c3026349f4, topicName=DWI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Mon Mar 11 14:06:00 CST 2013, time=2013-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341516, encodeId=aecc13415161d, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Mar 11 14:06:00 CST 2013, time=2013-03-11, status=1, ipAttribution=)]
    2013-03-11 hyf028
  4. [GetPortalCommentsPageByObjectIdResponse(id=2049954, encodeId=ca2e204995450, content=<a href='/topic/show?id=7620149192b' target=_blank style='color:#2F92EE;'>#PWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14919, encryptionId=7620149192b, topicName=PWI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Wed Jul 24 02:06:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784149, encodeId=d0201e84149cb, content=<a href='/topic/show?id=9aa3582177' target=_blank style='color:#2F92EE;'>#DEFUSE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5821, encryptionId=9aa3582177, topicName=DEFUSE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ca5383, createdName=bbjsj_1979, createdTime=Sat Jul 20 15:06:00 CST 2013, time=2013-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278699, encodeId=609912e869914, content=<a href='/topic/show?id=c3026349f4' target=_blank style='color:#2F92EE;'>#DWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6349, encryptionId=c3026349f4, topicName=DWI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Mon Mar 11 14:06:00 CST 2013, time=2013-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341516, encodeId=aecc13415161d, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Mar 11 14:06:00 CST 2013, time=2013-03-11, status=1, ipAttribution=)]