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Diabetologia：肝脏胰岛素抵抗减弱了空腹血浆胰高血糖素和胰高血糖素氨基酸之间的关系

2018-04-12 MedSci MedSci原创

胰高血糖素
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近日，国际杂志 《Diabetologia》上在线发表一项来自人类肝脏-α细胞轴的证据--肝脏胰岛素抵抗减弱了空腹血浆胰高血糖素和胰高血糖素氨基酸之间的关系的研究。 胰高血糖素的分泌受血糖控制，并且胰高血糖素的异常分泌会导致糖尿病中的高血糖症。除了其在葡萄糖调节中的作用外，胰高血糖素还可通过增加尿素合成作用来调节肝细胞中的氨基酸代谢。破坏这种机制的平衡会导致高氨基酸血症，继而增加胰高血糖素分

近日，国际杂志 《Diabetologia》上在线发表一项来自人类肝脏-α细胞轴的证据--肝脏胰岛素抵抗减弱了空腹血浆胰高血糖素和胰高血糖素氨基酸之间的关系的研究。 胰高血糖素的分泌受血糖控制，并且胰高血糖素的异常分泌会导致糖尿病中的高血糖症。除了其在葡萄糖调节中的作用外，胰高血糖素还可通过增加尿素合成作用来调节肝细胞中的氨基酸代谢。破坏这种机制的平衡会导致高氨基酸血症，继而增加胰高血糖素分泌。研究人员假设通过有缺陷的胰高血糖素信号传导/胰高血糖素抵抗导致的肝胰岛素抵抗（继发于肝脂肪变性）将导致受损的尿素生成，并且因此增加血浆胰高血糖素氨基酸浓度以及随后的胰高血糖素。 为了检查胰高血糖素和氨基酸之间的关联性，并探讨这种关系是否被肝胰岛素抵抗所改变，研究人员对一组1408个具有正常和异常的葡萄糖调节的个体开展了研究。在这个队列中，研究人员以前曾报道国胰岛素抵抗会伴随血浆胰高血糖素浓度的增加。因此，研究人员现在对同一队列中的血浆氨基酸水平进行测量。并以HOMA-IR作为肝胰岛素抵抗的标志物。 空腹水平的胰高血糖素氨基酸和胰高血糖素在线性回归模型中显著负相关（在校正年龄，性别和BMI后持续存

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    2019-01-19 zhaohui6731

    #氨基酸#

    0

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    2018-09-17 ms5439512287675881

    #BET#

    0

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    2018-06-08 baoya

    #胰岛#

    0

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    2018-11-04 ms9608593228839890

    #DIA#

    0

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    2018-04-14 hbwxf

    #高血糖#

    0

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    2018-04-14 sjzlzc009

    #胰高血糖素#

    0

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