J Rheumatol:系统性红斑狼疮的认知损害筛查试验

2017-09-11 xiangting MedSci原创

CI是非常普遍的,MoCA可作为筛选SLE中CI的有用工具。

临床上需要对系统性红斑狼疮(SLE)患者进行认知功能筛查测试。这项研究的目的是确定(1)通过蒙特利尔认知评估(MoCA),迷你精神状态检查(MMSE)与霍普金斯语言学习测试修订(HVLT-R)和感知缺陷问卷调查问卷5项(PDQ-5)确定SLE中认知障碍(CI)的患病率;和(2)与CI相关的因素。

纳入单中心随访的连续患者。进行HVLT-R、MoCA和MMSE测试。确定MoCA/MMSE的敏感性/特异性,阳性(PPV)/阴性(NPV)预测值和阳性似然比(LR +)(与HVLT-R相比)。对焦虑、抑郁和认知缺陷问题的知识能力测试和调查问卷。回归分析确定与CI的关联。

98例患者中,使用MoCA 48%有CI,使用HVLT-R 31%有CI。与MMSE(27%)相比,MoCA(73%)敏感性较高,尽管MMSE比MoCA(63%)特异性更高(90%)。MoCA和MMSE的PPV和LR +(PPV:47%,53%; LR +:2.0,2.6)相似,但MoCA的NPV(84%)高于MMSE(74%)。PDQ-5预测目标CI(HVLT-R:灵敏性100%,特异性89%)。尽管CI在单因素分析中与抑郁相关,但在多变量分析中并不存在相关性,然而SLE病程长和受教育年限长仍有显著关联。

CI是非常普遍的,MoCA可作为筛选SLE中CI的有用工具。受教育年限长的患者患CI的可能性更低。

原始出处:
Stephanie G. Nantes, et al. Performance of Screening Tests for Cognitive Impairment in Systemic Lupus Erythematosus. J Rheumatol. 01 September 2017. 

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    2017-09-13 zhouqu_8
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    2017-09-11 131****1460

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