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UROLOGY：低风险非肌肉侵袭性膀胱癌的主动监测可行并且有效

2018-02-22 MedSci MedSci原创

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最近有一项前瞻性观察研究监测了有病理证实的pTa(1-2级)或pT1a(2级) 阶段非肌肉浸润性膀胱癌的患者。主要终点是主动监测发现癌症的复发。评估失败预测变量和每年直接医院资源消耗是次要结果。采用单变量和多变量分析的描述性统计分析和Cox回归模型分析。

最近有一项前瞻性观察研究监测了有病理证实的pTa(1-2级)或pT1a(2级) 阶段非肌肉浸润性膀胱癌的患者。主要终点是主动监测发现癌症的复发。评估失败预测变量和每年直接医院资源消耗是次要结果。采用单变量和多变量分析的描述性统计分析和Cox回归模型分析。

在625例非肌肉浸润性膀胱癌中，共有146例活动监测患者纳入了该方案，59(40.4%)名患者被认为需要在进入主动监测后进行治疗。活动监测的中位时间为11个月(IQR 5-26)。目前76名患者(62.3%)仍在观察中。在单变量分析中，仅从第一个经确定的切除到主动监测开始的时间似乎与无复发生存率呈负相关(HR 0.99， 95% CI 0.98-1.00， p = 0.027)。多变量分析还揭示了在主动监测开始时的年龄(HR 0.97， 95% CI 0.94-1.00， p = 0.031)和第一次经尿道切除的病变大小(HR 1.55， 95% CI 1.06-2.27， p = 0.025)。

结论
对低等级的pTa/pT1a复发性乳头状膀胱肿瘤患者实行积极的监测可能是一种合理的临床策略。

原始出处：
Rodolfo Hurle.et al.Active Surveillance for Low Risk Nonmuscle Invasive Bladder Cancer： A Confirmatory and Resource Consumption Study from the BIAS Project.UROLOGY.2018.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1366291, encodeId=930f13662913a, content=<a href='/topic/show?id=186126998e2' target=_blank style='color:#2F92EE;'>#侵袭性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26998, encryptionId=186126998e2, topicName=侵袭性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Sat Feb 24 12:40:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506578, encodeId=3d6a15065e854, content=<a href='/topic/show?id=d4b923144d0' target=_blank style='color:#2F92EE;'>#主动监测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23144, encryptionId=d4b923144d0, topicName=主动监测)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d419776525, createdName=linne323, createdTime=Sat Feb 24 12:40:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290162, encodeId=e0f529016272, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Feb 23 08:37:50 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290160, encodeId=7e5a29016018, content=临床检测.AS,对于任何疾病都是有一定的必要性, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Fri Feb 23 08:35:24 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290014, encodeId=97b8290014aa, content=最近有一项前瞻性观察研究监测了有病理证实的pTa(1-2级)或pT1a(2级)阶段非肌肉浸润性膀胱癌的患者.主要终点是主动监测发现癌症的复发.评估失败预测变量和每年直接医院资源消耗是次要结果.采用单变量和多变量分析的描述性统计分析和Cox回归模型分析., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Feb 22 22:32:21 CST 2018, time=2018-02-22, status=1, ipAttribution=)]
    2018-02-24 sunyl07

    #侵袭性#

    0

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    2018-02-24 linne323

    #主动监测#

    0

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    2018-02-23 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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    2018-02-23 梦想起航ing

    临床检测.AS,对于任何疾病都是有一定的必要性

    0

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    2018-02-22 有备才能无患

    最近有一项前瞻性观察研究监测了有病理证实的pTa(1-2级)或pT1a(2级)阶段非肌肉浸润性膀胱癌的患者.主要终点是主动监测发现癌症的复发.评估失败预测变量和每年直接医院资源消耗是次要结果.采用单变量和多变量分析的描述性统计分析和Cox回归模型分析.

    0

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