肺血管阻力是预测植入ICD心衰患者预后新指标

2018-08-12 朱柳媛 中国循环杂志

南京市第一医院学者发表的一项研究表明,肺血管阻力(PVR)升高不仅是左心衰竭患者植入埋藏式心脏复律除颤器(ICD)后出现室速并接受ICD 恰当治疗的独立危险因素,还是该类患者因心衰再住院或全因死亡复合事件的独立预测因素,因此可用来预测ICD植入后患者的预后。

南京市第一医院学者发表的一项研究表明,肺血管阻力(PVR)升高不仅是左心衰竭患者植入埋藏式心脏复律除颤器(ICD)后出现室速并接受ICD 恰当治疗的独立危险因素,还是该类患者因心衰再住院或全因死亡复合事件的独立预测因素,因此可用来预测ICD植入后患者的预后。

该研究纳入因左心衰竭植入ICD 或心脏再同步化治疗除颤器(CRT-D)进行一级或二级预防的122例患者。

平均随访4.2 年期间,36 例(29.5%)患者共记录到121次ICD 恰当治疗,这些患者的平均PVR明显高于未出现室速并接受ICD恰当治疗的患者(3.1WUs vs 2.4 WUs)。

分析显示,PVR ≥ 2.5 WUs 的患者植入ICD 后出现室速并接受ICD 恰当治疗的发生率明显高于PVR<2.5WUs的患者(45.2% vs 13.2%)。

多因素Cox 回归分析表明,PVR 是左心衰竭患者植入ICD 后出现室速并接受ICD 恰当治疗的独立危险因素(HR=1.630,95% CI:1.170~2.010,P <0.01)。

随访期间,29 例(23.7%)患者因心衰再住院共31 次,18 例(14.7%)患者死亡。在PVR ≥ 2.5 WUs 的患者中,24 例(38.7%)死亡或因心衰再住院, 而在PVR<2.5WUs的患者中,仅7 例(11.7%)死亡或因心衰再住院。

多因素Cox 回归分析显示,PVR 是心衰患者植入ICD 后因心衰再住院或死亡复合事件的独立预测因素(HR=2.030,95% CI:1.210~3.120,P<0.01)。

原始出处:
陈灏璟,张娟,潘昌,等. 血管阻力对左心衰竭患者植入埋藏式心脏复律除颤器后室性心律失常事件的预测价值. 中国循环杂志, 2018, 33: 694-699.


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    2019-03-25 yilong5287542
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    2018-08-14 jiyangfei
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    2018-08-13 smartxiuxiu

    有意思

    0

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    2018-08-13 飛歌

    学习了很有用不错

    0

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    2018-08-12 329523732

    不错

    0

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    2018-08-12 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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