Cell stem report:星型胶质细胞分泌过量IL-6或是双向情感障碍治疗新靶点! 

2021-03-09 MedSci原创 MedSci原创

在双相情感障碍患者体内,IL-6至少在一定程度上介导了致炎性星形胶质细胞对神经元活动的影响。

双相情感障碍,也被称为躁郁症,它是一种精神疾病,特征是患者的情绪状态总是在躁狂与抑郁间循环往复。在全世界范围内,大约有1%~3%的人患有双相情感障碍,但截至目前,双相情感障碍的病因还没有被完全知晓。  双相患者患慢性炎症以及炎症相关疾病如心血管疾病、糖尿病和代谢综合征的概率较高。此外,他们具有更高浓度的促炎细胞因子,如IL-1β和IL-6,特别是在躁狂发作期间。  近日,美国索尔克生物研究所的一个研究小组在cell stem report上发表题为Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes的研究论文。  研究结果显示,星形胶质细胞过量分泌的一种叫做白细胞介素-6(IL-6)的促炎分子参与了脑内的炎症级联反应过程,星形胶质细胞分泌因子在调节神经元活动中发挥作用,在双相情感障碍患者体内,IL-6至少在一定程度上介导了致炎性星形胶质细胞对神经元活动的影响。 刺激性炎症使BD星形胶质细胞中IL-6释放增加 研究人员

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    2024-03-16 ms3000002096557062 来自四川省

    学习了

    0

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    2021-08-22 维他命
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  5. 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topicId=null, topicList=[TopicDto(id=84074, encryptionId=acf3840e459, topicName=胶质细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/DC48AC6B5FFD609EED5594C15A97B420/100, createdBy=57dc2500034, createdName=ms1692212821629096, createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391648, encodeId=27db1391648aa, content=<a href='/topic/show?id=6a363e435bb' target=_blank style='color:#2F92EE;'>#双向情感障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37435, encryptionId=6a363e435bb, topicName=双向情感障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1482319, encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-15 124219b2m20暂无昵称

    学习了

    0

  6. 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encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-10 kzlchina
  7. 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    2021-03-10 lsndxfj
  8. 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