Lancet Diab & Endo：1型糖尿病患者警惕：女性并发症率与死亡率高于男性

2015-02-06 MedSci MedSci原创

既往的研究已经提出了1型糖尿病相关的死亡率有着性别差异。基于这个背景，澳大利亚昆士兰大学的Huxley教授对女性和男性1型糖尿病患者的总体死亡率与血管事件的风险进行了一项系统综述和Meta分析，期望对1型糖尿病造成的全因死亡率风险和导致特定结果的风险在不同性别中的差异提供可靠的估计。该结果在线发表于2015年2月5日的The Lancet Diabetes & Endocrinology杂

既往的研究已经提出了1型糖尿病相关的死亡率有着性别差异。基于这个背景，澳大利亚昆士兰大学的Huxley教授对女性和男性1型糖尿病患者的总体死亡率与血管事件的风险进行了一项系统综述和Meta分析，期望对1型糖尿病造成的全因死亡率风险和导致特定结果的风险在不同性别中的差异提供可靠的估计。该结果在线发表于2015年2月5日的The Lancet Diabetes & Endocrinology杂志上。

作者从Pubmed上系统地选择了1966年1月1日至2014年11月26日间发表的相关研究。被选入的研究结果分别报道了与1型糖尿病相关的全因死亡率或导致特定结果的标准化死亡比（SMR）或危害比（HR）的性别特异性的预估。他们使用了随机效应的Meta分析与方差分析加权法来评价性别特异性SMR以及其全因的、心血管疾病、肾病、肿瘤、事故和自杀、1性糖尿病相关突发冠心病和中风等的合并比（女性比男性）。

本分析共选取了26项符合条件的研究，数据包含了214,114例患者，15,273次事件。全因死亡率SMR的女/男比为1.37（95% CI 1.21–1.56）；突发中风比为1.37（1.03-1.81）；致死性肾病比为1.44（1.02-2.05）；致死性心血管疾病比为1.86（1.62-2.15）。对于突发性冠心病，性别差异表现十分明显，死亡率SMR的女/男比为2.54（95% CI 1.80-3.60）。而肿瘤、意外或自杀与1型糖尿病相关死亡率未显示出性别差异。

结果表明，患有1型糖尿病的女性的全因死亡率较男性高出近40 %，而致死性或非致死性的血管事件的发生率接近男性的2倍，应引起患者和临床工作者警惕。

原始出处

Rachel R Huxley,Sanne A E Peters,Gita D Mishra,Mark Woodward. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis.The Lancet Diabetes & Endocrinology, 2015.2.5

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2015-04-11 howi

#Lancet#

38 0
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2015-09-20 丁鹏鹏

#并发#

31 0
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2015-06-13 18619c0a62m

不会吧

140 0
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2015-04-11 x35042875

AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性

183 0
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2015-06-28 millore

#1型糖尿病患者#

35 0
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2015-02-22 orthoW

不错的文章，学习了

98 0
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2015-02-17 chinayinhan

已阅

152 0
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2015-02-16 windmilL1989

赞

124 0
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2015-02-08 xjtumed10

谢谢，学习了

62 0
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2015-02-08 xue8604

#糖尿病患者#

36 0

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