Lancet :多学科共同研发心脏疾病干细胞疗法

2012-03-12 MedSci MedSci原创

本周《柳叶刀》杂志发表文章称,为将心脏疾病再生治疗方法实现其有效性,目前多学科展开了密切合作。但关键是克服现有的科研专业领域之间的传统障碍,从科研和私营部门建立的跨学科团队。 该论文的第一作者、美国哈佛大学Kenneth Chien解释说:开展扭转晚期心脏衰竭再生战略的是本世纪最迫切的临床需求之一,已成为现代心血管科学的圣杯。但如果我们要让干细胞生物学运用到真正的心血管再生疗法中,我么有

本周《柳叶刀》杂志发表文章称,为将心脏疾病再生治疗方法实现其有效性,目前多学科展开了密切合作。但关键是克服现有的科研专业领域之间的传统障碍,从科研和私营部门建立的跨学科团队。 该论文的第一作者、美国哈佛大学Kenneth Chien解释说:开展扭转晚期心脏衰竭再生战略的是本世纪最迫切的临床需求之一,已成为现代心血管科学的圣杯。但如果我们要让干细胞生物学运用到真正的心血管再生疗法中,我么有必要努力改变现有的科研学术氛围和环境。 到现在为止,已经有临床试验围绕心脏病发作、慢性心功能衰竭以及扩张性心肌病展开研究,虽然结果表明针对各种非心肌细胞类型设计的再生疗法似乎是安全的,但其疗效尚未在临床试验中测试。 然而,由于在心脏干细胞研究和再生生物学上研究取得了新进展,心脏病的治疗可能会出现新的治疗靶标和治疗策略。 科学家们过去认为心脏只有很小的自我更新能力,人们在扭转健康心脏肌肉和功能的丧失上处于消极态度。但由于最近的调查结果发现如心脏中有几种不同类型的胚胎祖细胞,上述看法将会改变。 心肌损伤的人体内存在一定数量的上述细胞被激活现象,现在科学家希望通过细胞转化或通过激活和转换有功能的心脏细胞等方法

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    2013-02-24 howi
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    2012-03-14 lqvr
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     美国凯斯西储大学医学院的研究人员通过动物模型确定了维系室性心律失常与昼夜节律的Klf15分子,据此,可解释某些心血管事件,特别是那些具有潜在心律失常病因的心血管事件发生在清晨数小时的原因。在转录因子Kruppel样因子15(Klf15)的调控下,心脏离子通道表达和QT间期表现出一种内源性昼夜节律特征。这项研究发表于2012年2月22日的《自然》上。 &

Chem Comm:含硒糖对人心脏有益

澳大利亚墨尔本大学自由基化学和生物技术ARC卓越中心(ARC Centre of Excellence for Free Radical Chemistry and Biotechnology at The University of Melbourne)柯林-斯多克(Corin Storkey)博士和卡尔-席塞尔(Carl Schiesser)教授的最新研究表明一种新类型的糖可能有助于阻止心脏病