AJG:男性循环性激素水平和食管腺癌风险

2020-01-27 不详 MedSci原创

有研究显示性激素在男性食管腺癌发病中占主导地位,因此,本项研究探究了循环性激素水平如何影响食管腺癌的未来风险。

目标:
有研究显示性激素在男性食管腺癌发病中占主导地位,因此,本项研究探究了循环性激素水平如何影响食管腺癌的未来风险。

方法:
本项病例对照研究纳入了挪威人群的队列,其中包括244例男性食管腺癌患者和244例年龄匹配的男性参与者。研究人员使用条件对数回归评估了12种性激素的诊断前循环水平与食管腺癌风险之间的关联。

结果:
研究显示,食管腺癌与睾丸激素(OR = 0.44,95%置信区间[CI] 0.22–0.88),雌二醇比(OR = 0.37,95%CI 0.19–0.72)明显相关,调整吸烟和体育锻炼后,发现促黄体激素(OR = 0.50,95%CI 0.30–0.98)也与食管癌有关。进一步调整体重指数后,这些相关性减弱(睾丸激素为OR = 0.56,95%CI 0.27–1.13;睾丸激素:雌二醇比为OR = 0.46,95%CI 0.23–0.91;)。性激素结合球蛋白,硫酸脱氢表雄酮,卵泡刺激素,催乳素,17-OH孕酮,孕酮,雄烯二酮或游离睾丸激素指数均未发现相关性。

讨论:
本研究发现较高的循环睾丸激素水平可降低男性食道腺癌的风险。

原始出处:

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    2020-03-07 minzju5052
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    2020-01-29 zhouqu_8
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体力衰弱在肝硬化患者中普遍存在,据推测部分原因是肌肉减少症所致,但人们对肌肉减少症对衰弱的确切贡献知之甚少。因此,本项研究旨在探究二者的关系。

AJG:年轻男性的性激素结合球蛋白水平与中年非酒精性脂肪肝相关

有研究数据显示,患有非酒精性脂肪性肝病(NAFLD)的男性睾酮和性激素结合球蛋白(SHBG)水平较低。目前尚不清楚年轻男性的性激素水平是否可预测NAFLD的预后结局,因此,本项研究旨在探究这二者之间的关系。