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Diabetologia：脐带血代谢标志物是孕产妇肥胖对妊娠期胎儿生长影响的强有力的调节物

2020-04-12 MedSci原创 MedSci原创

脐带血；代谢标志物；孕产妇肥胖
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本研究的目的是评估脐带血代谢标记物与胎儿过度生长之间的关系，以及脐带标记是否介导了母亲肥胖对土著和非土著澳大利亚妇女正常糖耐量(NGT)、妊娠期糖尿病(GDM)和孕前2型糖尿病所生儿童的新生儿人体测量

本研究的目的是评估脐带血代谢标记物与胎儿过度生长之间的关系，以及脐带标记是否介导了母亲肥胖对土著和非土著澳大利亚妇女正常糖耐量(NGT)、妊娠期糖尿病(GDM)和孕前2型糖尿病所生儿童的新生儿人体测量结果的影响。

在澳大利亚(PANDORA)的妊娠和新生儿结局研究中，1135对母婴观察队列中，有645名患有NGT (n = 129)、GDM (n = 419)和2型糖尿病(n = 97)的女性独生子女(49%澳大利亚本地人)可获得静脉血脐带血。测定脐带葡萄糖、甘油三酸酯、高密度脂蛋白胆固醇、c反应蛋白(CRP)和c肽。采用多变量logistic和线性回归分析脐带血代谢指标与出生体重z评分、皮肤层厚度总和(SSF)、胎龄(LGA)及体脂百分比之间的关系。采用途径分析评估脐带标记物是否介导了孕产妇和新生儿肥胖之间的关联。            

在调整年龄、种族和糖尿病类型后，脐带C肽升高与出生体重z评分(β0.57[95%CI0.42，0.71])、SS F(β0.83[95%CI0.41，1.25])、体脂百分比(β1.20[95%CI0.69，1.71])和LGA风险(OR3.14[95%CI2.11，4.68])显著相关。 三酰甘油与澳大利亚土著妇女出生体重z评分呈负相关。脐带葡萄糖、高密度脂蛋白胆固醇和CRP>0.3mg/l(2.9nmol/l)与新生儿结局无相关性。C肽介导18%(95%CI13，36)母体BMI与LGA的关联，11%(95%CI8，17)与新生儿脂肪的关联。

研究结果表明，脐带血c肽是母体糖耐量谱中母婴肥胖关系的重要中介物质。

原始出处：

I-Lynn Lee, Elizabeth L. M. Barr,Cord blood metabolic markers are strong mediators of the effect of maternal adiposity on fetal growth in pregnancies across the glucose tolerance spectrum: the PANDORA study

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    2020-10-05 hukaixun

    #标志物#

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    2020-08-10 ms5439512287675881

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    2020-06-17 124987c6m36暂无昵称

    #代谢标志物#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1841499, encodeId=045c18414997b, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Oct 05 05:40:34 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761376, encodeId=9aec1e61376f8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Aug 10 06:40:34 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639424, encodeId=2b721639424b4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 14 00:40:34 CST 2020, time=2020-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956510, encodeId=6c0e195651055, content=<a href='/topic/show?id=ff682544ec4' target=_blank style='color:#2F92EE;'>#代谢标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25447, encryptionId=ff682544ec4, topicName=代谢标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Wed Jun 17 03:40:34 CST 2020, time=2020-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251247, encodeId=aaa3125124e18, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355174, encodeId=e68313551e4a3, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542420, encodeId=bbf2154242041, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=)]
    2020-04-14 wjcjjian

    #妊娠期#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1841499, encodeId=045c18414997b, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Oct 05 05:40:34 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761376, encodeId=9aec1e61376f8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Aug 10 06:40:34 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639424, encodeId=2b721639424b4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 14 00:40:34 CST 2020, time=2020-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956510, encodeId=6c0e195651055, content=<a href='/topic/show?id=ff682544ec4' target=_blank style='color:#2F92EE;'>#代谢标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25447, encryptionId=ff682544ec4, topicName=代谢标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Wed Jun 17 03:40:34 CST 2020, time=2020-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251247, encodeId=aaa3125124e18, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355174, encodeId=e68313551e4a3, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542420, encodeId=bbf2154242041, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=)]
    2020-04-14 zhaojie88

    #脐带血#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1841499, encodeId=045c18414997b, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Oct 05 05:40:34 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761376, encodeId=9aec1e61376f8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Aug 10 06:40:34 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639424, encodeId=2b721639424b4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 14 00:40:34 CST 2020, time=2020-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956510, encodeId=6c0e195651055, content=<a href='/topic/show?id=ff682544ec4' target=_blank style='color:#2F92EE;'>#代谢标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25447, encryptionId=ff682544ec4, topicName=代谢标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Wed Jun 17 03:40:34 CST 2020, time=2020-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251247, encodeId=aaa3125124e18, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355174, encodeId=e68313551e4a3, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542420, encodeId=bbf2154242041, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Apr 14 11:40:34 CST 2020, time=2020-04-14, status=1, ipAttribution=)]
    2020-04-14 1249859em42(暂无昵称)

    #脐带#

    0