NAT COMMUN:长达12年的追踪:老年人中多病症的临床轨迹

2020-07-04 MedSci原创 MedSci原创

最近,研究人员识别了多发病群,追踪其在老年人中的演变过程,并检测了单个个体在12年内的临床轨迹和死亡率。

多病症,即多种疾病并存,经常与预后不良有关,但由于我们对其随时间发展的了解很少,阻碍了有效的临床干预。

最近,研究人员识别了多发病群,追踪其在老年人中的演变过程,并检测了单个个体在12年内的临床轨迹和死亡率。

通过模糊c-means聚类算法,研究人员将2931名年龄≥60岁的人归入5个有临床意义的多发病聚类(52%)。其余48%属于非特异性聚类(即所有疾病都不占过多比例),这极大地帮助了随访时其他聚类的发展。聚类簇对其他簇的纵向发展和死亡率的贡献不同。

研究人员报告说,多发病群及其轨迹可能有助于识别具有相似需求和预后的同质人群,并帮助临床医生和卫生保健系统进行个性化的临床干预和预防策略。

 

原始出处:

Davide L. Vetrano et al. Twelve-year clinical trajectories of multimorbidity in a population of older adults, Nature Communications (2020). 

 

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    2021-05-27 liuli5079
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    2021-02-02 liye789132251
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