Stroke:中国成人抑郁发作与卒中风险的相关性研究

2016-09-26 MedSci MedSci原创

这个大型的前瞻性研究表明,重性抑郁发作的存在是卒中的一个危险因素,尤其是在吸烟者群体中更为明显。

虽然抑郁症和中风风险之间的关系已有文章进行报道,但在之前的报道中,调查结果存在相互矛盾的地方。近日,卒中领域权威杂志《Stroke》上发表了来自中国学者的文章,旨在探究中国成人重症抑郁发作与卒中风险的相关性以及评估中国人抑郁症数量和卒中风险的关系。

该研究共纳入199 294名男性和288 083名女性,年龄在30~79岁,无卒中、心脏病和肿瘤病史。根据精神疾病诊断与统计手册IV标准,采用世界卫生组织复合性国际诊断访谈量表来评估重性抑郁发作情况,通过死亡证明、医疗记录和健康保险数据确定脑卒中事件。


研究者发现在完全校正模型中,去年重症抑郁发作与增加15%的中风风险轻微相关(校正后的危险比为1.15;95%置信区间为0.99–1.33),在年龄小于50岁、吸烟、饮酒,具有较高的受教育程度、身体质量指数小于24Kg/m2以及无糖尿病史的参与者中,该相关性越来越显著,而且在抑郁症状数量和增加的卒中风险存在正性量效关系(Ptrend=0.011)。此外,吸烟状况与重性抑郁发作存在相互作用影响卒中发病(P=0.025)。

这个大型的前瞻性研究表明,重症抑郁发作的存在是卒中的一个危险因素,尤其是在吸烟者群体中更为明显。

原始出处:

Jie Sun, et al. Association of Major Depressive Episodes With Stroke Risk in a Prospective Study of 0.5 Million Chinese Adults. Stroke. 2016. http://dx.doi.org/10.1161/STROKEAHA.116.013512

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    2016-10-12 1e10c84am36(暂无匿称)

    好文章,受益

    0

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