DIABETOLOGIA：怀孕期间母体代谢产物与新生儿结局和整个家族中的高胰岛素血症有关

2019-04-03 不详网络

本研究目的是确定母亲代谢产物与新生儿肥胖和高胰岛素血症在血统家族母亲-新生儿中的关联。 <span style="font-size:12.0pt;font-family:宋体;mso-ascii-font-family: Calibri;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:宋体;mso-fareast-them

本研究目的是确定母亲代谢产物与新生儿肥胖和高胰岛素血症在血统家族母亲-新生儿中的关联。

针对参与高血糖和不良妊娠结局的四个血统组（北欧，非洲裔加勒比，墨西哥裔美国人和泰国）的1600名母亲在禁食和1小时血清样本进行了靶向和非靶向代谢组学分析（HAPO）研究，在妊娠〜28周接受OGTT，其新生儿在出生时进行人体测量。

结果显示，在这项观察性研究中，分析显示母亲禁食和1小时代谢物与出生体重，脐带C肽和/或整个血统的皮肤褶皱总数显著相关。特别是，母亲禁食三酰基甘油与新生儿皮肤褶皱相关。在1小时时，几种氨基酸，脂肪酸和脂质代谢物与一种或多种新生儿结果相关。网络分析显示，与脐带c肽、皮肤皱褶和相关的禁食酰基肉碱、氨基酸、脂类和脂肪酸代谢物簇，并在1h时，加入支链和芳香氨基酸。

怀孕期间的母体代谢组与新生儿结局有关。怀孕期间母体的氨基酸，酰基肉碱，脂质和脂肪酸及其代谢物水平与胎儿生长，肥胖和脐带C肽有关，与母体BMI和血糖水平无关。

原始出处：

Rachel Kadakia, Michael Nodzenski, Octavious Talbot, Alan Kuang. Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

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2020-01-31 ms9608593228839890

#DIA#

24 0
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2019-12-28 baoya

#胰岛#

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2019-12-12 ms5439512287675881

#BET#

30 0
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2019-04-05 124987c6m39暂无昵称

#代谢产物#

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2019-04-04 SCI我的梦

谢谢分享

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