Clin Nutr:催产素鼻内喷一喷,轻松减少食物摄入量!

2021-10-12 Nebula MedSci原创

单次经鼻予以催产素可明显减少非精神病患者的食物摄入量

内源性催产素(OT)的升高与焦虑和饭量减少有关,经鼻予以催产素在食物摄入和食欲管理方面的影响已得到了验证。但是,经鼻予以催产素在不同疾病人群中的作用差异尚不完全清楚。

本研究通过系统检索PubMed、Embase和Cochrane Library数据库,筛选到12项对照研究。研究人员对这些研究进行了荟萃分析以评估经鼻予以催产素后受试者的食物摄入量、食欲、焦虑或压力的变化情况。

这12项研究共涵盖了266位非精神病患者和157名精神病患者。汇总结果显示,单次经鼻予以催产素可使非精神病患者的食物摄入量显著减少(标准平均差[SMD] -0.66, 95% CI -1.18~-0.14),但在神经性厌食症(SMD 0.17)、神经性暴食症和饮食混乱障碍(-0.41)以及精神分裂症(0.04)患者中未观察到该效果。对休闲食品的进一步分析也表明,经鼻予以催产素可限制非精神病患者对巧克力饼干的摄入量。

催产素组和安慰剂组受试者食物摄入量的变化

与安慰剂组相比,经鼻予以催产素对各亚组(非精神病组、神经性暴食症组、饮食混乱障碍组和精神分裂症组)受试者的食欲或饥饿感的影响均无显著差异。 最后,无论是在任何亚组,经鼻予以催产素对焦虑或压力水平也均无明显影响。

综上所述,单次经鼻予以催产素可明显减少非精神病患者的食物摄入量,有必要进一步评估经鼻予以催产素对肥胖患者的长期作用和安全性。但是,经鼻予以催产素是否适用于饮食障碍患者还需要进一步探索。

原始出处:

Chen Chi-Ying,Chiang Yu-Chen,Kuo Tai-Chih et al. Effects of intranasal oxytocin in food intake and craving: A meta-analysis of clinical trials.[J] .Clin Nutr, 2021, 40: 5407-5416.

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    2022-03-20 lmm397
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    2021-10-14 yhy100201
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    2021-10-14 zhanfl
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    2021-10-13 youchuangang

    了解了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1860720, encodeId=c4cd1860e2080, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Mar 20 04:14:09 CST 2022, time=2022-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416918, encodeId=9f3a141691813, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Thu Oct 14 14:14:09 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529949, encodeId=9c5115299495f, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Thu Oct 14 14:14:09 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060122, encodeId=5c14106012211, content=了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210803/c8bd21d131874f2da2b414237aacbc9f/f1217872050c44a685f25fc392e53669.jpg, createdBy=154f1995399, createdName=youchuangang, createdTime=Wed Oct 13 14:10:47 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060001, encodeId=80d91060001d9, content=们我佛泳裤看家具辣鸡8人。!…, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Wed Oct 13 06:44:03 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059992, encodeId=1b7210599924c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Wed Oct 13 06:08:43 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059976, encodeId=458510599e64c, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Oct 12 23:56:26 CST 2021, time=2021-10-12, status=1, ipAttribution=)]
    2021-10-13 查查佳佳

    们我佛泳裤看家具辣鸡8人。!…

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1860720, encodeId=c4cd1860e2080, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Mar 20 04:14:09 CST 2022, time=2022-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416918, encodeId=9f3a141691813, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Thu Oct 14 14:14:09 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529949, encodeId=9c5115299495f, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Thu Oct 14 14:14:09 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060122, encodeId=5c14106012211, content=了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210803/c8bd21d131874f2da2b414237aacbc9f/f1217872050c44a685f25fc392e53669.jpg, createdBy=154f1995399, createdName=youchuangang, createdTime=Wed Oct 13 14:10:47 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060001, encodeId=80d91060001d9, content=们我佛泳裤看家具辣鸡8人。!…, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Wed Oct 13 06:44:03 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059992, encodeId=1b7210599924c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Wed Oct 13 06:08:43 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059976, encodeId=458510599e64c, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Oct 12 23:56:26 CST 2021, time=2021-10-12, status=1, ipAttribution=)]
    2021-10-13 与狼共舞

    学习学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1860720, encodeId=c4cd1860e2080, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Mar 20 04:14:09 CST 2022, time=2022-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416918, encodeId=9f3a141691813, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Thu Oct 14 14:14:09 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529949, encodeId=9c5115299495f, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Thu Oct 14 14:14:09 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060122, encodeId=5c14106012211, content=了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210803/c8bd21d131874f2da2b414237aacbc9f/f1217872050c44a685f25fc392e53669.jpg, createdBy=154f1995399, createdName=youchuangang, createdTime=Wed Oct 13 14:10:47 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060001, encodeId=80d91060001d9, content=们我佛泳裤看家具辣鸡8人。!…, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Wed Oct 13 06:44:03 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059992, encodeId=1b7210599924c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Wed Oct 13 06:08:43 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059976, encodeId=458510599e64c, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Oct 12 23:56:26 CST 2021, time=2021-10-12, status=1, ipAttribution=)]
    2021-10-12 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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