ACC2011:导管消融对阵发性房颤发展的影响

2011-05-07 MedSci原创 MedSci原创

目的:确定射频消融对阵发性房颤发展的影响。 背景:50%的阵发性房颤接受药物治疗后可能发展为持续性房颤。高血压,年龄,既往短暂性缺血性时间,慢性阻塞性肺疾病和心力衰竭(HATCH评分)均被确立为房颤发展的独立危险因素。 方法:504名房颤患者(年龄58±10岁)接受RFA治疗以消除阵发性房颤。193名患者(38%)接受再次消融手术。采用多因素分析评估各临床因素对RFA后结果的预测价值以及它们与房颤

目的:确定射频消融对阵发性房颤发展的影响。
背景:50%的阵发性房颤接受药物治疗后可能发展为持续性房颤。高血压,年龄,既往短暂性缺血性时间,慢性阻塞性肺疾病和心力衰竭(HATCH评分)均被确立为房颤发展的独立危险因素。
方法:504名房颤患者(年龄58±10岁)接受RFA治疗以消除阵发性房颤。193名患者(38%)接受再次消融手术。采用多因素分析评估各临床因素对RFA后结果的预测价值以及它们与房颤发展的关系。
结果:RFA后平均随访27±12个月,434/504 (86%)名患者维持窦性节律;49/504 (9.5%)名患者仍为阵发性房颤;14 (3%)名患者出现房扑.504名患者中,7 (1.5%)名患者发展为持续性房颤。在RFA后房颤复发的患者中,7/56 (13%, P<0.001)名患者发展为持续性房颤。RFA后阵发性房颤发展为持续性房颤的比例以每年0.6%增加,这与药物治疗相比明显降低(P<0.001)。年龄>75岁,房颤持续时间超过10年和糖尿病是发展为持续性房颤的独立预测因素。HATCH评分并不影响阵发性房颤发展为持续性房颤(P=0.03)。
结论:RFA和传统药物治疗阵发性房颤相比,更能减少其发展为持续性房颤的比率。年龄、房颤持续时间和糖尿病是RFA后阵发性房颤发展为持续性房颤的独立预测因素。HATCH评分并不能预测RFA后阵发性房颤发展为持续性房颤的可能,不应用于选择合适接受RFA的患者。

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辩论:早期导管消融可终止房颤进展?

MedSci:各种争论,恰是科研的起点。   正方观点 不要等到心房重构程度较重之后,再行导管消融治疗……   西班牙法雷(Farré)教授认为以下两个问题决定早期导管治疗是否可终止房颤进展。首先,房颤持续时间、心房重构程度及房颤复发风险间是否存在相关性?其次,导管消融成功是否可逆转心房重构?   2009年欧克斯(Oakes)等发表于《循环》杂志的一项研究或对上述第一个问题给出了肯定答