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阿尔茨海默病的脑微出血研究进展

2012-05-26 徐俊，张楚楚，时建铨 南京医科大学附属脑科医院

微出血阿尔茨海默病脑血管性痴呆
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【摘要】     阿尔茨海默病(AD)患者的脑微出血研究近来备受重视，因为病理学基础是脑淀粉样 血管病(CAA)。CAA作为衔接AD淀粉样蛋白假说和血管异常机制的核心病理学表现，近年来的临床病理学研究结果提示高度重视AD患者的CAA所致CMB情况，对于临床患者的管理和临床试验的指标设计有指导意义。 1. 脑微出血概念、病理特点及临床意义   &nb

【摘要】     阿尔茨海默病(AD)患者的脑微出血研究近来备受重视，因为病理学基础是脑淀粉样 血管病(CAA)。CAA作为衔接AD淀粉样蛋白假说和血管异常机制的核心病理学表现，近年来的临床病理学研究结果提示高度重视AD患者的CAA所致CMB情况，对于临床患者的管理和临床试验的指标设计有指导意义。 1. 脑微出血概念、病理特点及临床意义     脑微出血（cerebral microbleeds, CMB）是脑内微小血管病变所致、以微量出血为主要特点的一种脑实质亚临床损害[1]。上世纪90年代磁共振T2加权梯度回波成像（gradient-echo magnetic resonance imaging, GRE-MRI）技术的应用可促进脑微出血的检出：CMB在GRE序列上的表现为均匀一致直径2～5mm的卵圆形信号减低区，周围无水肿[2]。目前的研究资料认为微小血管周围的含铁血黄素沉积或吞噬有含铁血黄素的单核细胞，少数可能有微动脉瘤、细小动脉透明变性或淀粉样物质沉积是造成GRE序列上信号缺失的主要病理学基础[3]。CMB可见于脑内

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    2013-04-04 12498da4m32(暂无昵称)

    #阿尔茨海#

    0

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    2013-01-01 liuxiaona

    #微出血#

    0

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    2013-03-02 ms1948154235210413

    #阿尔茨#

    0

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    2012-06-25 limin4784

    为何没出现参考文献呢？

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1817547, encodeId=3750181e54792, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Apr 04 03:38:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1674829, encodeId=efbd16e482920, content=<a href='/topic/show?id=60fb50501b3' target=_blank style='color:#2F92EE;'>#微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50501, encryptionId=60fb50501b3, topicName=微出血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c7927121733, createdName=liuxiaona, createdTime=Tue Jan 01 10:38:00 CST 2013, time=2013-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816524, encodeId=060c1816524b7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Mar 02 12:38:00 CST 2013, time=2013-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4408, encodeId=b2614408d9, content=为何没出现参考文献呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbbe63219, createdName=limin4784, createdTime=Mon Jun 25 15:30:00 CST 2012, time=2012-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380359, encodeId=ddfa138035936, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393532, encodeId=5d41139353259, content=<a href='/topic/show?id=7ee28485472' target=_blank style='color:#2F92EE;'>#脑微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84854, encryptionId=7ee28485472, topicName=脑微出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469901, encodeId=262a14699013c, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=)]
    2012-05-28 mashirong

    #研究进展#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1817547, encodeId=3750181e54792, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Apr 04 03:38:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1674829, encodeId=efbd16e482920, content=<a href='/topic/show?id=60fb50501b3' target=_blank style='color:#2F92EE;'>#微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50501, encryptionId=60fb50501b3, topicName=微出血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c7927121733, createdName=liuxiaona, createdTime=Tue Jan 01 10:38:00 CST 2013, time=2013-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816524, encodeId=060c1816524b7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Mar 02 12:38:00 CST 2013, time=2013-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4408, encodeId=b2614408d9, content=为何没出现参考文献呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbbe63219, createdName=limin4784, createdTime=Mon Jun 25 15:30:00 CST 2012, time=2012-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380359, encodeId=ddfa138035936, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393532, encodeId=5d41139353259, content=<a href='/topic/show?id=7ee28485472' target=_blank style='color:#2F92EE;'>#脑微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84854, encryptionId=7ee28485472, topicName=脑微出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469901, encodeId=262a14699013c, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=)]
    2012-05-28 12498b08m90暂无昵称

    #脑微出血#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1817547, encodeId=3750181e54792, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Apr 04 03:38:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1674829, encodeId=efbd16e482920, content=<a href='/topic/show?id=60fb50501b3' target=_blank style='color:#2F92EE;'>#微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50501, encryptionId=60fb50501b3, topicName=微出血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c7927121733, createdName=liuxiaona, createdTime=Tue Jan 01 10:38:00 CST 2013, time=2013-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816524, encodeId=060c1816524b7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Mar 02 12:38:00 CST 2013, time=2013-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4408, encodeId=b2614408d9, content=为何没出现参考文献呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbbe63219, createdName=limin4784, createdTime=Mon Jun 25 15:30:00 CST 2012, time=2012-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380359, encodeId=ddfa138035936, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393532, encodeId=5d41139353259, content=<a href='/topic/show?id=7ee28485472' target=_blank style='color:#2F92EE;'>#脑微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84854, encryptionId=7ee28485472, topicName=脑微出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469901, encodeId=262a14699013c, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon May 28 12:38:00 CST 2012, time=2012-05-28, status=1, ipAttribution=)]
    2012-05-28 yhj-time

    #阿尔茨海默#

    0