Radiology:中度创伤性脑损伤后女性工作记忆预后更差

2015-10-10 phylis 译 MedSci原创

背景:评估中度创伤性脑损伤后(MTBI)工作记忆的性别差异。方法:研究伦理委员会批准,患者签署知情同意书。应用功能磁共振MI评估30名MTBI患者(15名男性,15名女性)及30名对照组受试者(15名男性,15名女性)的工作记忆。对患者进行两次功能磁共振扫描,最初在损伤1月后进行扫描,进行随访,在第一次扫描后6周进行第二次扫描。每个受试者,在进行功能MR扫描前,进行数字广度和连续执行测试。应用Kr

背景:评估中度创伤性脑损伤后(MTBI)工作记忆的性别差异。

方法:研究伦理委员会批准,患者签署知情同意书。应用功能磁共振MI评估30名MTBI患者(15名男性,15名女性)及30名对照组受试者(15名男性,15名女性)的工作记忆。对患者进行两次功能磁共振扫描,最初在损伤1月后进行扫描,进行随访,在第一次扫描后6周进行第二次扫描。每个受试者,在进行功能MR扫描前,进行数字广度和连续执行测试。应用Kruskal-Wallis、 Whitney U检验、Wilcoxon秩和检验、Fisher精确检验进行数据分析。分别用用单样本,双样本t检验对功能MR进行组内和组间差异分析。

结果:在女性受试者中,MTBI组的数字广度得分低于对照组。在最初的工作记忆功能MR研究中,与对照组男性性比,MTBI组男性患者存在高反应性;与女性对照组性比,在MTBI女性组中出现低反应性。6周的随访研究中,女性MTBI组患者存在持续低反应性,而在活性图中显示MTBI男性组中出现高反应性下降的趋势。男性MTBI组的最初研究的ß值高于男性对照组,而随访研究中,男性MTBI组和男性对照组ß 值没有出现差异。女性MTBI组,最初研究和随访研究的ß 值均低于女性对照组,但是没有统计学差异。

结论:女性MTBI患者数字广度测试分数低于女性对照组,功能MR显示工作记忆存在性别差异;MTBI女性患者随访研究中显示低反应性未恢复可能表明不良的工作记忆预后。

原文出处

Hui-Ling Hsu, David Yen-Ting Chen, Ying-Chi Tseng, et al. Sex Differences in Working Memory after Mild Traumatic Brain Injury: A Functional MR Imaging Study. Radiology. September, 2015.


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  5. [GetPortalCommentsPageByObjectIdResponse(id=2025423, encodeId=be8220254238d, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Jun 03 17:39:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691619, encodeId=a2e21691619d3, content=<a href='/topic/show?id=1a594e91229' target=_blank style='color:#2F92EE;'>#工作记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47912, encryptionId=1a594e91229, topicName=工作记忆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Sep 22 23:39:00 CST 2016, time=2016-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335086, encodeId=1dd6133508617, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Mon Oct 12 00:39:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396947, encodeId=e1af139694e3a, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Oct 12 00:39:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38341, encodeId=83b23834163, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:17:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38338, encodeId=a93438338f6, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38339, encodeId=916438339b1, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38340, encodeId=2ceb3834048, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=)]
    2015-10-11 hlycom3356

    感谢作者分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2025423, encodeId=be8220254238d, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Jun 03 17:39:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691619, encodeId=a2e21691619d3, content=<a href='/topic/show?id=1a594e91229' target=_blank style='color:#2F92EE;'>#工作记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47912, encryptionId=1a594e91229, topicName=工作记忆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Sep 22 23:39:00 CST 2016, time=2016-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335086, encodeId=1dd6133508617, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Mon Oct 12 00:39:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396947, encodeId=e1af139694e3a, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Oct 12 00:39:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38341, encodeId=83b23834163, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:17:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38338, encodeId=a93438338f6, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38339, encodeId=916438339b1, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38340, encodeId=2ceb3834048, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=)]
    2015-10-11 hlycom3356

    感谢作者分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2025423, encodeId=be8220254238d, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Jun 03 17:39:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691619, encodeId=a2e21691619d3, content=<a href='/topic/show?id=1a594e91229' target=_blank style='color:#2F92EE;'>#工作记忆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47912, encryptionId=1a594e91229, topicName=工作记忆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Sep 22 23:39:00 CST 2016, time=2016-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335086, encodeId=1dd6133508617, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Mon Oct 12 00:39:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396947, encodeId=e1af139694e3a, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Oct 12 00:39:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38341, encodeId=83b23834163, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:17:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38338, encodeId=a93438338f6, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38339, encodeId=916438339b1, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38340, encodeId=2ceb3834048, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 15:16:00 CST 2015, time=2015-10-11, status=1, ipAttribution=)]
    2015-10-11 hlycom3356

    感谢作者分享

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    2015-10-11 hlycom3356

    感谢作者分享

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