Gut:ω- 3多不饱和脂肪酸大量摄入可能降低结直肠癌死亡风险

2016-08-22 MedSci BMJ

尽管结直肠癌的治疗方式不断进步,但其仍然是导致死亡较多的主要癌症之一。据统计,在美国,2015年因结直肠癌死亡的人数达49,700人,列肿瘤死亡原因中第三位。目前大量证据显示饮食和生活方式影响结直肠癌的发生,但这些因素是否同样对结直肠癌的生存产生影响仍不得而知。因此,了解影响结直肠癌预后的一些可调控因素,对于癌症诊断后提高生存预后有十分重要的意义。ω- 3多不饱和脂肪酸,包括EPA,已经在实验室中

尽管结直肠癌的治疗方式不断进步,但其仍然是导致死亡较多的主要癌症之一。据统计,在美国,2015年因结直肠癌死亡的人数达49,700人,列肿瘤死亡原因中第三位。目前大量证据显示饮食和生活方式影响结直肠癌的发生,但这些因素是否同样对结直肠癌的生存产生影响仍不得而知。因此,了解影响结直肠癌预后的一些可调控因素,对于癌症诊断后提高生存预后有十分重要的意义。

ω- 3多不饱和脂肪酸,包括EPA,已经在实验室中被证实可以抑制肿瘤生长和血管生成。有报道称,补充ω- 3多不饱和脂肪酸有助于增强结直肠癌化疗药物的抗肿瘤效果。

BMJ旗下著名期刊Gut 近日发表一篇文章,探究了结直肠癌诊断后补充ω- 3多不饱和脂肪酸与肿瘤死亡率降低是否存在关联这一问题。

研究选取了美国Nurses’ Health Study 和 Health Professionals Follow-up Study两个队列,共1659人诊断结直肠癌。研究发现,大量摄入ω- 3多不饱和脂肪酸与结直肠癌死亡风险下降存在关联(趋势p =0.03)。每天摄入0.30 gω- 3多不饱和脂肪酸与摄入<0.10 g相比,死亡风险调整后HR值0.59 (95% CI 0.35- 1.01)。

研究结论:对于结直肠癌患者增加ω- 3多不饱和脂肪酸摄入可能有潜在好处。

原始出处:Song M, Zhang X, Meyerhardt JA, et al. Marine ω-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis. Gut 2016;0:1–7.

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  5. 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encodeId=911815e99617f, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Wed Aug 24 02:22:00 CST 2016, time=2016-08-24, status=1, ipAttribution=)]
    2016-08-30 李东泽

    很好,不错,以后会多学习

    0

  6. 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encodeId=911815e99617f, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Wed Aug 24 02:22:00 CST 2016, time=2016-08-24, status=1, ipAttribution=)]
    2016-08-24 lwzsh

    好用

    0

  7. 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