JAHA:抗抑郁药物类型与心血管疾病发病率的关系

2019-05-29 xing.T 网络

由此可见,与服用非SSRI抗抑郁药相比,服用SSRI与CVD的风险降低无关。与三环类和其他非SSRI抗抑郁药相比,这些结果并没有支持SSRIs与CVD风险相关的证据。

抗抑郁药物类型与血管疾病(CVD)风险的关联尚不清楚。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员假设相比于三环类和其他非SSRI抗抑郁药,选择性5-羟色胺再摄取抑制剂(SSRIs)与CVD事件风险较低有关。

研究人员分析了1987年至2013年间某些时间点用抗抑郁药物治疗的ARIC(社区动脉粥样硬化风险)研究中的2027名参与者(平均年龄为63±10岁; 29%为男性; 78%为白人)。研究人员确定了受试者中的CVD事件,包括心房颤动、心力衰竭、心肌梗塞和缺血性卒中,并使用风险比来比较SSRIs服用者(47%)与非SSRI服用者调整社会人口统计学指标和临床​​危险因素的CVD事件。

参与者从服用抗抑郁药开始到2016年,服药时间的中位数为13.5年。研究人员确定了332例心房颤动,365例心力衰竭,174例心肌梗死和119例缺血性卒中事件。SSRIs和非SSRI抗抑郁药使用者的CVD风险相似(心房颤动风险比为1.10; 95%CI为0.86-1.41;心力衰竭风险比为0.98; 95%CI为0.77-1.25;心肌梗死风险比为0.91;95%CI为0.64-1.29;缺血性卒中的风险比为1.07; 95%CI为0.70-1.63)。

由此可见,与服用非SSRI抗抑郁药相比,服用SSRI与CVD的风险降低无关。与三环类和其他非SSRI抗抑郁药相比,这些结果并没有支持SSRIs与CVD风险相关的证据。 

原始出处:

Zakaria Almuwaqqat.et al.Association of Antidepressant Medication Type With the Incidence of Cardiovascular Disease in the ARIC Study.JAHA.2019.https://www.ahajournals.org/doi/10.1161/JAHA.119.012503

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    2020-04-12 wetgdt
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    2019-05-31 zhaohui6731
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