Am J Gastroenterol:结肠镜检查可显著降低人群结直肠癌发生率和死亡率

2016-01-24 Mechront 译 MedSci原创

观察性研究显示,结肠镜检查可减少总体人群的结直肠癌(CRC)发生率和死亡率。研究者检索了PubMed、EMBASE等数据库相关文献,进行荟萃分析量化结肠镜检查的保护幅度。研究以整体CRC发病率和患病率为主要结局指标,使用随机效应模型计算合并后RRs和95%CI。荟萃分析共纳入11篇观察性研究,涉及1,499,521名参与者。合并后荟萃分析结果显示,结肠镜检查可减少非恶性发现患者61%的CRC发生风

观察性研究显示,结肠镜检查可减少总体人群的结直肠癌(CRC)发生率和死亡率。研究者检索了PubMed、EMBASE等数据库相关文献,进行荟萃分析量化结肠镜检查的保护幅度。研究以整体CRC发病率和患病率为主要结局指标,使用随机效应模型计算合并后RRs和95%CI。

荟萃分析共纳入11篇观察性研究,涉及1,499,521名参与者。合并后荟萃分析结果显示,结肠镜检查可减少非恶性发现患者61%的CRC发生风险 (RR: 0.39; 95% CI: 0.26-0.60; I2=93.6%) 和61%死亡风险(RR: 0.39; 95% CI: 0.35-0.43; I2=12.0%),不过关于CRC发生率的研究之间异质性较高。剔除离群值的研究后,发生率结局间的异质性降低 (I2=44.7%)。亚组分析结果显示,结肠镜筛查比诊断性结肠镜检查(RR: 0.51; 95% CI: 0.43-0.59; P<0.001)的效果更加突出,可减少89%的CRC发生风险(RR: 0.11; 95% CI: 0.08-0.15)。

该篇纳入观察性研究的荟萃分析表明,非恶性发现的人群中,结肠镜检查可显著降低整体CRC发生率和死亡率。此外结肠镜筛查比诊断性结肠镜检查可显著的降低CRC的发生。

原始出处:

Pan J, Xin L, Ma YF,et al.Colonoscopy Reduces Colorectal Cancer Incidence and Mortality in Patients With Non-Malignant Findings: A Meta-Analysis.Am J Gastroenterol. 2016 Jan 12. doi: 10.1038/ajg.2015.418. 


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createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61278, encodeId=039e612e8df, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61279, encodeId=1205612e945, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434420, encodeId=f2cd1434420d9, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Jan 26 14:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452784, encodeId=6e361452e8485, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue Jan 26 14:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-10-08 许安
  5. 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content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Jan 26 14:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452784, encodeId=6e361452e8485, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue Jan 26 14:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-27 doctording1

    不错,赞一个

    0

  6. 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createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61278, encodeId=039e612e8df, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61279, encodeId=1205612e945, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434420, encodeId=f2cd1434420d9, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Jan 26 14:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452784, encodeId=6e361452e8485, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue Jan 26 14:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-27 doctording1

    这篇文章有一定深度

    0

  7. 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createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61278, encodeId=039e612e8df, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61279, encodeId=1205612e945, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:01:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434420, encodeId=f2cd1434420d9, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Jan 26 14:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452784, encodeId=6e361452e8485, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Tue Jan 26 14:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-27 doctording1

    是一篇不错的文章

    0

  8. 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    2016-01-27 doctording1

    值得进一步关注

    0

  9. 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    2016-01-26 zhouqu_8
  10. 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