Arthritis & Rheumatol:类风湿关节炎患者胰岛素抵抗增加

2014-12-29 佚名 生物谷

类风湿关节炎(RA)患者具有胰岛素抵抗(IR)升高现象,但这类患者胰岛素抵抗升高是不与动脉粥样硬化风险增加相关联,相关研究刊登在Arthritis & Rheumatology杂志上。 哥伦比亚大学Jon T. Giles,MD和同事比较95例RA患者和统计学匹配的98名非RA对照组之间IR情况,使用HOMA胰岛素抵抗(HOMA-IR)指数评价胰岛素抵抗程度,HOMA-IR即稳态模型胰

类风湿关节炎(RA)患者具有胰岛素抵抗(IR)升高现象,但这类患者胰岛素抵抗升高是不与动脉粥样硬化风险增加相关联,相关研究刊登在Arthritis & Rheumatology杂志上。

哥伦比亚大学Jon T. Giles,MD和同事比较95例RA患者和统计学匹配的98名非RA对照组之间IR情况,使用HOMA胰岛素抵抗(HOMA-IR)指数评价胰岛素抵抗程度,HOMA-IR即稳态模型胰岛素抵抗指数。

研究人员发现,平均HOMA-IR水平在RA组中高出31%,在对照组中,HOMA-IR和与C-反应蛋白和白细胞介素-6水平有关,但这种关联在RA组中较弱。

在那些类风湿性关节炎患者中,HOMA-IR升高与男性和女性的类风湿因子阳性相关,以及与妇女是否使用泼尼松相关。在平均3.2年的随访中,RA患者之间,基线和平均HOMA-IR都不与动脉粥样硬化风险增加相关。 虽然RA的IR高于非RA,但更高水平的IR可能不会单独增加动脉粥样硬化风险。

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    2015-05-18 baoya
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    2014-12-31 lmm397
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    2014-12-31 智智灵药
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