Clinica Chimica Acta:评估中国老年蛋白尿患者肾小球滤过率和肾小管功能障碍

2019-09-22 gladiator MedSci原创

目前,尚无对中国老年人群中等白蛋白尿肾损害的发生率及临床危险因素的研究。为了阐明这一点,我们对中国社区老年人口进行了调查研究。 <span style="font-size:12.0pt;mso-bidi-font-size:14.0pt; font-family:宋体;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;

目前,尚无对中国老年人群中等白蛋白尿肾损害的发生率及临床危险因素的研究。为了阐明这一点,我们对中国社区老年人口进行了调查研究。

本研究共纳入691名老年社区参与者。将Normoalbuminuria定义为晨尿尿白蛋白肌酐比值(ACR) < 30 毫克/克。评估老年人群的肾小球滤过率(eGFR)和尿-1微球蛋白肌酐比值(MCR),以评估正常蛋白尿肾损害。

在整个队列中,30.25%的患者有蛋白尿,8.68%的患者eGFR降低,49.78%的患者MCR升高。正常白蛋白尿受试者也表现出低eGFRMCR升高的高患病率(eGFR降低6.02%MCR升高37.55%)。在正常白蛋白尿患者中,MCR升高的患病率最高的是糖尿病患者(50%),而低eGFR的患病率最高的是女性(8.11%)normoalbuminuric之间没有显著差异。年龄、性别、糖尿病高血压均为MCR升高的独立危险因素。糖尿病高血压eGFR降低无统计学影响,而性别对eGFR降低的风险最高。

研究表明,蛋白尿作为肾损伤的筛查指标可能作用有限,因为尽管有正常蛋白尿,仍有相当比例的老年人存在肾功能损害。正常白蛋白尿肾损害不应只关注糖尿病或高血压患者,而应在整个老年人群中给予更多关注。

原始出处:

Huabin WangYingjie LouEstimating the glomerular filtration rate and tubular dysfunction in an elderly population with normoalbuminuria in China

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1808891, encodeId=637a180889125, content=<a href='/topic/show?id=9d788252695' target=_blank style='color:#2F92EE;'>#肾小球滤过#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82526, encryptionId=9d788252695, topicName=肾小球滤过)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sat Jun 20 10:56:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849746, encodeId=32741849e4677, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Jul 03 22:56:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808901, encodeId=11e51808901cc, content=<a href='/topic/show?id=ade982539bd' target=_blank style='color:#2F92EE;'>#肾小管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82539, encryptionId=ade982539bd, topicName=肾小管功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sun May 17 15:56:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080284, encodeId=1677208028463, content=<a href='/topic/show?id=73b88253ed5' target=_blank style='color:#2F92EE;'>#肾小管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82537, encryptionId=73b88253ed5, topicName=肾小管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Tue Dec 31 19:56:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421253, encodeId=f1d114212537d, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440290, encodeId=93e8144029011, content=<a href='/topic/show?id=659b8252ebb' target=_blank style='color:#2F92EE;'>#肾小球滤过率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82527, encryptionId=659b8252ebb, topicName=肾小球滤过率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a744719690, createdName=1249897bm38(暂无昵称), createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1808891, encodeId=637a180889125, content=<a href='/topic/show?id=9d788252695' target=_blank style='color:#2F92EE;'>#肾小球滤过#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82526, encryptionId=9d788252695, topicName=肾小球滤过)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sat Jun 20 10:56:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849746, encodeId=32741849e4677, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Jul 03 22:56:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808901, encodeId=11e51808901cc, content=<a href='/topic/show?id=ade982539bd' target=_blank style='color:#2F92EE;'>#肾小管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82539, encryptionId=ade982539bd, topicName=肾小管功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sun May 17 15:56:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080284, encodeId=1677208028463, content=<a href='/topic/show?id=73b88253ed5' target=_blank style='color:#2F92EE;'>#肾小管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82537, encryptionId=73b88253ed5, topicName=肾小管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Tue Dec 31 19:56:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421253, encodeId=f1d114212537d, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440290, encodeId=93e8144029011, content=<a href='/topic/show?id=659b8252ebb' target=_blank style='color:#2F92EE;'>#肾小球滤过率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82527, encryptionId=659b8252ebb, topicName=肾小球滤过率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a744719690, createdName=1249897bm38(暂无昵称), createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
    2020-07-03 windight
  3. [GetPortalCommentsPageByObjectIdResponse(id=1808891, encodeId=637a180889125, content=<a href='/topic/show?id=9d788252695' target=_blank style='color:#2F92EE;'>#肾小球滤过#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82526, encryptionId=9d788252695, topicName=肾小球滤过)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sat Jun 20 10:56:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849746, encodeId=32741849e4677, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Jul 03 22:56:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808901, encodeId=11e51808901cc, content=<a href='/topic/show?id=ade982539bd' target=_blank style='color:#2F92EE;'>#肾小管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82539, encryptionId=ade982539bd, topicName=肾小管功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sun May 17 15:56:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080284, encodeId=1677208028463, content=<a href='/topic/show?id=73b88253ed5' target=_blank style='color:#2F92EE;'>#肾小管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82537, encryptionId=73b88253ed5, topicName=肾小管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Tue Dec 31 19:56:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421253, encodeId=f1d114212537d, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440290, encodeId=93e8144029011, content=<a href='/topic/show?id=659b8252ebb' target=_blank style='color:#2F92EE;'>#肾小球滤过率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82527, encryptionId=659b8252ebb, topicName=肾小球滤过率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a744719690, createdName=1249897bm38(暂无昵称), createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1808891, encodeId=637a180889125, content=<a href='/topic/show?id=9d788252695' target=_blank style='color:#2F92EE;'>#肾小球滤过#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82526, encryptionId=9d788252695, topicName=肾小球滤过)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sat Jun 20 10:56:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849746, encodeId=32741849e4677, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Jul 03 22:56:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808901, encodeId=11e51808901cc, content=<a href='/topic/show?id=ade982539bd' target=_blank style='color:#2F92EE;'>#肾小管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82539, encryptionId=ade982539bd, topicName=肾小管功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sun May 17 15:56:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080284, encodeId=1677208028463, content=<a href='/topic/show?id=73b88253ed5' target=_blank style='color:#2F92EE;'>#肾小管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82537, encryptionId=73b88253ed5, topicName=肾小管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Tue Dec 31 19:56:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421253, encodeId=f1d114212537d, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440290, encodeId=93e8144029011, content=<a href='/topic/show?id=659b8252ebb' target=_blank style='color:#2F92EE;'>#肾小球滤过率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82527, encryptionId=659b8252ebb, topicName=肾小球滤过率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a744719690, createdName=1249897bm38(暂无昵称), createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1808891, encodeId=637a180889125, content=<a href='/topic/show?id=9d788252695' target=_blank style='color:#2F92EE;'>#肾小球滤过#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82526, encryptionId=9d788252695, topicName=肾小球滤过)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sat Jun 20 10:56:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849746, encodeId=32741849e4677, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Jul 03 22:56:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808901, encodeId=11e51808901cc, content=<a href='/topic/show?id=ade982539bd' target=_blank style='color:#2F92EE;'>#肾小管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82539, encryptionId=ade982539bd, topicName=肾小管功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sun May 17 15:56:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080284, encodeId=1677208028463, content=<a href='/topic/show?id=73b88253ed5' target=_blank style='color:#2F92EE;'>#肾小管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82537, encryptionId=73b88253ed5, topicName=肾小管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Tue Dec 31 19:56:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421253, encodeId=f1d114212537d, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440290, encodeId=93e8144029011, content=<a href='/topic/show?id=659b8252ebb' target=_blank style='color:#2F92EE;'>#肾小球滤过率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82527, encryptionId=659b8252ebb, topicName=肾小球滤过率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a744719690, createdName=1249897bm38(暂无昵称), createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1808891, encodeId=637a180889125, content=<a href='/topic/show?id=9d788252695' target=_blank style='color:#2F92EE;'>#肾小球滤过#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82526, encryptionId=9d788252695, topicName=肾小球滤过)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sat Jun 20 10:56:00 CST 2020, time=2020-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849746, encodeId=32741849e4677, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Jul 03 22:56:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808901, encodeId=11e51808901cc, content=<a href='/topic/show?id=ade982539bd' target=_blank style='color:#2F92EE;'>#肾小管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82539, encryptionId=ade982539bd, topicName=肾小管功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sun May 17 15:56:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080284, encodeId=1677208028463, content=<a href='/topic/show?id=73b88253ed5' target=_blank style='color:#2F92EE;'>#肾小管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82537, encryptionId=73b88253ed5, topicName=肾小管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Tue Dec 31 19:56:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421253, encodeId=f1d114212537d, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440290, encodeId=93e8144029011, content=<a href='/topic/show?id=659b8252ebb' target=_blank style='color:#2F92EE;'>#肾小球滤过率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82527, encryptionId=659b8252ebb, topicName=肾小球滤过率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a744719690, createdName=1249897bm38(暂无昵称), createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]

相关资讯

JASN:华中科大陈历明课题组发文揭示HCO3–重吸收新机制

近日,华中科技大学陈历明教授课题组在美国肾脏学会会刊Journal of American Society of Nephrology(IF=8.491)发表研究论文,揭示了近端肾小管存在一种新的HCO3–重吸收机制。CO2/HCO3–是机体中最主要的酸碱缓冲体系,提供了机体中约70%的酸碱缓冲能力。生理条件下血液中[HCO3–]为24 mM,血液pH为7.4左右。机体每天通过饮食会摄入过量的酸,

糖尿病肾病肾小管细胞形态功能异常的研究进展

糖尿病肾病(DKD)是终末期肾病(ESRD)的主要原因。虽然肾小球损伤在DKD 的发病机制中处于中心地位,但目前许多学者认为,肾小管及间质病变也是2型糖尿病患者病理生理改变的重要组成部分,且临床与动物实验证明小管病变在DKD的进展中起关键作用。 DKD状态下,肾小管上皮细胞形态与功能异常表现为:肾小管上皮细胞生长异常,葡萄糖及钠的重吸收功能紊乱及小管间质纤维化等,这些病理改变与DKD 的进展

JASN:miR-200下调导致Pkd1表达破坏肾小管成熟

    美国德克萨斯大学西南医学中心的Vishal Patel等研究了小分子RNA(miRNA)对于肾脏形成后期的肾小管成熟的影响。结果发现,从成熟的肾小管中去除miRNA处理的关键酶Dicer,会导致小鼠产生肾小管和肾小球的囊泡。     Dicer酶的失活会引起miRNA-200的下调(一个肾脏内富含的miRNA家族成员),并上调多