Stroke:短暂性脑缺血发作患者非局灶性症状需谨慎

2018-08-02 国际循环编辑部 国际循环

短暂性脑缺血发作(TIA)患者有时出现非局灶性症状,如失去知觉,健忘症和不稳定症状。Stroke杂志发表的一项最新研究,采用PROMISE-TIA研究(前瞻性、多中心、登记识别TIA发作后的心血管事件)数据,以阐明具有非局灶性症状的TIA患者的特征和预后。

短暂性脑缺血发作(TIA)患者有时出现非局灶性症状,如失去知觉,健忘症和不稳定症状。Stroke杂志发表的一项最新研究,采用PROMISE-TIA研究(前瞻性、多中心、登记识别TIA发作后的心血管事件)数据,以阐明具有非局灶性症状的TIA患者的特征和预后。

研究共计纳入日本全国登记处发病后7天内的TIA患者,校正多变量因素后评估与非局灶性症状相关的1年缺血性卒中和冠状动脉疾病风险因素。结果,1362例TIA患者[879例男性;平均年龄(69±12)岁],其中219例(16%)出现非局灶性症状。

与没有非局灶性症状的患者相比,出现非局灶性症状的TIA患者在后循环扩散加权成像(多变量校正OR=3.07;95%CI:1.57~5.82)和后循环动脉狭窄或闭塞中更可能显示急性缺血性病变(OR=1.94;95%CI:1.19~3.09)。虽组间患者的1年缺血性卒中风险无显著差异(校正HR=0.79;95%CI:0.42~1.37),但非局部性症状TIA患者冠状动脉疾病风险更高(HR=3.37;95%CI:1.14~9.03)。

研究提示,急性缺血性病变和动脉狭窄以及后循环闭塞病变更常见于伴有非局灶性症状的TIA患者。

原始出处:
Toshiya Ishihara, Shoichiro Sato, Toshiyuki Uehara, et al. Significance of Nonfocal Symptoms in Patients With Transient Ischemic Attack. Stroke. July 16, 2018.


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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:09:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336399, encodeId=d7da336399e8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Aug 04 19:07:04 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336391, encodeId=9ee9336391b8, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 04 16:48:05 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
  5. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:09:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336399, encodeId=d7da336399e8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Aug 04 19:07:04 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336391, encodeId=9ee9336391b8, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 04 16:48:05 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-09-18 jyzxjiangqin

    短暂性脑缺血发作。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1819234, encodeId=f7d9181923465, content=<a href='/topic/show?id=8a5099394aa' target=_blank style='color:#2F92EE;'>#非局灶性症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99394, encryptionId=8a5099394aa, topicName=非局灶性症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sun Oct 07 10:23:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764525, encodeId=13071e6452597, content=<a href='/topic/show?id=1612e319263' target=_blank style='color:#2F92EE;'>#短暂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73192, encryptionId=1612e319263, topicName=短暂性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:09:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336399, encodeId=d7da336399e8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Aug 04 19:07:04 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336391, encodeId=9ee9336391b8, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 04 16:48:05 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-31 jyzxjiangqin

    短暂性脑缺血发作患者。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1819234, encodeId=f7d9181923465, content=<a href='/topic/show?id=8a5099394aa' target=_blank style='color:#2F92EE;'>#非局灶性症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99394, encryptionId=8a5099394aa, topicName=非局灶性症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sun Oct 07 10:23:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764525, encodeId=13071e6452597, content=<a href='/topic/show?id=1612e319263' target=_blank style='color:#2F92EE;'>#短暂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73192, encryptionId=1612e319263, topicName=短暂性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Aug 31 20:36:42 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339387, encodeId=e71633938eec, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 18 21:09:22 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336500, encodeId=a8ff33650010, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:09:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336399, encodeId=d7da336399e8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Aug 04 19:07:04 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336391, encodeId=9ee9336391b8, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 04 16:48:05 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-18 jyzxjiangqin

    短暂性脑缺血发作。

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:09:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336399, encodeId=d7da336399e8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Aug 04 19:07:04 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336391, encodeId=9ee9336391b8, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 04 16:48:05 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-05 张新亮1853311252142e2fm

    好文章学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1819234, encodeId=f7d9181923465, content=<a href='/topic/show?id=8a5099394aa' target=_blank style='color:#2F92EE;'>#非局灶性症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99394, encryptionId=8a5099394aa, topicName=非局灶性症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sun Oct 07 10:23:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764525, encodeId=13071e6452597, content=<a href='/topic/show?id=1612e319263' target=_blank style='color:#2F92EE;'>#短暂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73192, encryptionId=1612e319263, topicName=短暂性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Aug 31 20:36:42 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339387, encodeId=e71633938eec, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 18 21:09:22 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336500, encodeId=a8ff33650010, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:09:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336399, encodeId=d7da336399e8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Aug 04 19:07:04 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336391, encodeId=9ee9336391b8, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 04 16:48:05 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-04 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Aug 31 20:36:42 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339387, encodeId=e71633938eec, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 18 21:09:22 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336500, encodeId=a8ff33650010, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sun Aug 05 07:09:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336399, encodeId=d7da336399e8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Aug 04 19:07:04 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336391, encodeId=9ee9336391b8, content=短暂性脑缺血发作。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 04 16:48:05 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-04 jyzxjiangqin

    短暂性脑缺血发作。

    0