AGS:老年人常见药物反应: 口干症

2017-11-02 MedSci MedSci原创

根据10月26日发表在《美国老年医学会杂志》(Journal of the American Geriatrics Society)上的一篇评论文章,在老年人中,药物使用与口腔干燥症和唾液腺功能障碍密切相关。来自澳大利亚的莫纳什大学的Edwin C.K. Tan博士,和他的同事们进行了系统的文献回顾(1990至2016)来识别老年人(年龄≥60)参加干预或观察研究药物的使用引起的口干或唾液腺功能减


根据10月26日发表在《美国老年医学会杂志》(Journal of the American Geriatrics Society)上的一篇评论文章,在老年人中,药物使用与口腔干燥症和唾液腺功能障碍密切相关。

来自澳大利亚的莫纳什大学的Edwin C.K. Tan博士,和他的同事们进行了系统的文献回顾(1990至2016)来识别老年人(年龄≥60)参加干预或观察研究中药物的使用引起的口干或唾液腺功能减退的不良反应。共有52项合格研究,其中26项被纳入荟萃分析。

研究人员发现,在干预研究中,泌尿系统药物(OR = 5.91),抗抑郁药(OR,4.74)和心理治疗(OR,2.59)与口干相关。在观察性研究中,一些药物的种类,以及服用药物的数量,与口干、唾液腺功能减退密切相关。总的来说,大多数研究被认为方法学质量中等。

作者总结说:"未来的研究应该为药物性口干提供风险评分,以辅助处方和药物管理。"


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