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JBC：浙江大学生科院解析Hippo抑癌通路

2013-10-18 佚名 浙江大学

Hippo抑癌浙江大学
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浙江大学生命科学研究院赵斌教授实验室2013年10月8日在Journal of Biological Chemistry杂志发表研究论文“Phosphorylation of angiomotin by Lats1/2 inhibits F-actin binding, cell migration and angiogenesis”，其中赵斌博士是本文通讯作者，硕士研究生

浙江大学生命科学研究院赵斌教授实验室2013年10月8日在Journal of Biological Chemistry杂志发表研究论文“Phosphorylation of angiomotin by Lats1/2 inhibits F-actin binding, cell migration and angiogenesis”，其中赵斌博士是本文通讯作者，硕士研究生代晓明是本文第一作者。【原文下载】

Hippo信号转导通路在器官大小调控、癌症发生、组织再生、以及干细胞的功能上发挥重要作用。该通路的核心部分是一个由Mst1/2和Lats1/2蛋白激酶组成的激酶链组成。激酶的生物学功能主要由底物决定，然而，除经典的YAP/TAZ转录辅激活因子以外，目前对Lats1/2下游底物的了解还非常少。

在本研究中，赵斌课题组发现Lats1/2激酶能够磷酸化angiomotin（AMOT）的HXRXXS保守基序。磷酸化后能够抑制AMOT与F-actin的直接结合，进而影响F-actin应力纤维与粘着斑的形成。进一步研究发现AMOT磷酸化以后，能够抑制血管内皮细胞的迁移，这与细胞骨架及细胞粘着在细胞迁移中的重要作用相吻合。发育过程中的血管生成依赖于细胞的迁移。体内研究表明AMOT磷酸化抑制斑马鱼的发育过程中的血管生成。

这一发现，鉴定出Hippo通路中新的下游底物AMOT，并且第一次报道了Hippo通路通过磷酸化AMOT调节血管的生成，扩展了对Hippo抑癌通路生理功能的认识。

原文检索：

Dai X, She P, Chi F, Feng Y, Liu H, Jin D, Zhao Y, Guo X, Jiang D, Guan KL, Zhong TP, Zhao B.Zhejiang University, China.Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration and angiogenesis.J Biol Chem. 2013 Oct 8.【原文下载】

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    2014-06-13 yykkxiaodou

    #大学生#

    0

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    2013-11-05 一闲

    #浙江大学#

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    2014-07-12 lily1616

    #JBC#

    0

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    2014-01-04 hongbochen

    #解析#

    0

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    2014-01-12 jingyanzhu715_39486108

    #抑癌#

    0