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Nat Commun：牙髓间充质干细胞中的甲基化和PTEN活化促进骨生成并减少肿瘤发生

2019-05-25 不详 网络

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谱系定型和肿瘤发生，区分干细胞的特征，尚未在源自人牙髓（DP-MSC）和骨髓（BM-MSC）的间充质干细胞中进行充分表征和比较。在这里，我们报告DP-MSCs表现出成骨潜能增加，脂肪形成潜力降低，形成牙本质牙髓样复合物，并且与BM-MSC相比具有抗致癌转化的能力。全基因组RNA-seq和差异表达分析揭示了脂肪细胞和成骨细胞分化通路，骨髓肿瘤通路和PTEN/PI3K/AKT通路的差异。DP-MSC中

谱系定型和肿瘤发生，区分干细胞的特征，尚未在源自人牙髓（DP-MSC）和骨髓（BM-MSC）的间充质干细胞中进行充分表征和比较。在这里，我们报告DP-MSCs表现出成骨潜能增加，脂肪形成潜力降低，形成牙本质牙髓样复合物，并且与BM-MSC相比具有抗致癌转化的能力。

全基因组RNA-seq和差异表达分析揭示了脂肪细胞和成骨细胞分化通路，骨髓肿瘤通路和PTEN/PI3K/AKT通路的差异。DP-MSC中比在BM-MSC中更高的PTEN表达是两种细胞中谱系定型和肿瘤发生差异的原因。此外，与DP-MSC相比，BM-MSC中的PTEN启动子表现出更高的DNA甲基化水平和抑制标记H3K9Me2富集，DP-MSC分别由增加的DNMT3B和G9a表达介导。

总之，该研究表明了几种表观遗传因子如何广泛影响谱系定型和肿瘤发生，在开发干细胞的治疗用途时应该考虑这些因素。

原始出处：

Shen WC, Lai YC, et al., Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesisand reduces oncogenesis. Nat Commun. 2019 May 20;10(1):2226. doi: 10.1038/s41467-019-10197-x.

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    2020-03-24 liuli5079

    #COMMUN#

    0

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    2019-07-23 liye789132251

    #Nat#

    0

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    2019-09-30 jxrzshh

    #牙髓#

    0

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    2020-03-07 h.y200607_23674418

    #间充质干细#

    0

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    2019-05-27 xiaogang317

    #PTEN#

    0