Diabetologia:犬尿氨酸:色氨酸比例作为冠状动脉疾病患者2型糖尿病预测因子

2017-09-30 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于犬尿氨酸:色氨酸比例作为冠状动脉疾病患者2型糖尿病预测因子的研究。

近日,国际杂志 《Diabetologia》上在线发表一项关于犬尿氨酸:色氨酸比例作为冠状动脉疾病患者2型糖尿病预测因子的研究。 色氨酸代谢物犬尿氨酸具有很强的免疫调节和血管活性。实验数据表明犬尿氨酸与肥胖病态相关。但关于其的流行病学研究却很少。研究人员评估了血浆和尿液犬尿氨酸:色氨酸比(KTR)与2型糖尿病的关联性。 研究人员跟踪了中位数为7.6年共2519无基础糖尿病的冠状动脉疾病患者(CAD;男性占73.1%),期间确定了173例(6.9%)新发生的2型糖尿病。应用多因素Cox回归分析来研究血浆和尿KTR与新发2型糖尿病的前瞻性关系。 研究结果显示,研究群体平均(SD)年龄为61.3(10.4)岁,BMI为25.9(3.71)kg/m 2,中位数(四分位数范围)HbA 1c为5.6%(5.0%-6.0%)(38 [31-42]mmol/mol)。血浆KTR与2型糖尿病风险无显著相关性。相比之下,尿KTR表现出强相关性。比较四分位数,HR(95%CI)分别在年龄和性别校正和多变量模型中分别为2.59(1.56,4.30)和2.35(1.39,3.96)。 研究表明,尿KTR是CAD

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