J Periodontal Res:低水平激光治疗辅助牙周非手术对于吸烟和非吸烟慢性牙周炎患者的治疗:半口,随机对照研究

2017-09-16 MedSci MedSci原创

本研究旨在调查低水平激光治疗(LLLT)作为吸烟和非吸烟慢性牙周炎患者的刮治和根面平整(SRP)治疗的辅助作用。

本研究旨在调查低水平激光治疗(LLLT)作为吸烟和非吸烟慢性牙周炎患者的刮治和根面平整(SRP)治疗的辅助作用。

材料与方法:该研究使用30例慢性牙周炎患者(15名吸烟者,15名非吸烟者)和30名相应年龄的健康个体进行分裂半口设计。分组如下:Cp + SRP +假手术:SRP治疗非吸烟慢性牙周炎患者; Cp + SRP + LLLT:SRP + LLLT治疗非吸烟慢性牙周炎患者; SCP + SRP +假手术:SRP治疗吸烟慢性牙周炎患者; SCP + SRP + LLLT:SRP + LLLT治疗吸烟慢性牙周炎患者; C:对照组由牙周健康的非吸烟者组成; SC:对照组由牙周健康的吸烟者组成。在SRP治疗后,第2天和第7天再次施用LLLT。在非手术牙周治疗之前和第30天时记录临床参数。牙周治疗之前和第7,14和30天的随访期间收集龈沟液样品。用酶联免疫吸附测定法测定龈沟液转化生长因子(TGF-β1),组织纤溶酶原激活物(tPA)和纤溶酶原激活物抑制剂1(PAI-1)水平。

结果:LLLT组和假手术组中所有临床参数均表现出SRP治疗前和30天时的显着地减少(P<0。001)。。吸烟者或非吸烟者的LLLT和假手术组之间无明显差异(P> 0.05)。 SCP + SRP +假手术组和SCP + SRP + LLLT组龈沟液PAI-1水平显着降低(P <0.05),Cp + SRP +假手术组,Cp + SRP + LLLT和SCp + SRP + LLLT组龈沟液tPA水平显着降低(P <0.05)。所有治疗组龈沟液TGF-β1水平均显着降低(P <0.05)。尽管在测量的任何时间点,LLLT与假手术组的龈沟液PAI-1,tPA和TGF-β1水平之间没有发现显着性差异(P> 0.05),但两组LLLT组均显示tPA / PAI-1比率随时间降低。

结论:在本研究的范围内,LLLT可能在调节牙周组织tPA和PAI-1龈沟液水平中发挥作用,特别是在吸烟的慢性牙周炎患者中,可以作为非牙周手术治疗的辅助。

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    2018-06-19 amyloid
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    2018-01-08 hyf028
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    2018-07-08 feather89
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    2017-09-18 oliver169
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