J Periodontol:BMI与广泛型侵袭性牙周炎之间的全新U型关系:一项横向研究

2018-07-22 lishiting MedSci原创

BMI与牙周炎之间的关系一直存在争议。有研究认为,不仅是过重/肥胖而且体重过低均与广泛型侵袭性牙周炎(GAgP)相关联。然而,BMI与GAgP之间确切的关系以及罹患GAgP最低风险的最佳BMI值还未可知。

BMI与牙周炎之间的关系一直存在争议。有研究认为,不仅是过重/肥胖而且体重过低均与广泛型侵袭性牙周炎(GAgP)相关联。然而,BMI与GAgP之间确切的关系以及罹患GAgP最低风险的最佳BMI值还未可知。

因此,这篇研究的目的是为了探讨在中国BMI与GAgP风险,牙周状况和WBC(白细胞)计数之间的确切关系,并找出与GAgP最低风险,牙周状态和最低WBC相关的最佳BMI值。

研究招募了300名GAgP患者和133名健康对照个体。准确测量受试者的身高与体重以计算BMI值。记录包含探诊深度(PD), 附着丧失水平(AL), 出血指数(BI)的临床牙周指标。通过血常规检查获得WBC。采用平滑曲线拟合和分段回归模型分析BMI和各变量之间的阈效应。使用曲线形态描述BMI与GAgP之间的关系。

结果显示,GAgP患者中BMI和GAgP风险, AL和WBC计数之间展现出U型关系。对于最低GAgP风险和最低WBC计数的最佳BMI值为22 kg/m2。当BMI在22至28 kg/m2之间时,每单位BMI增加后患者的GAgP风险增加39% (adjusted OR = 1.39, 95%CI: 1.17, 1.67),而当BMI在22至18 kg/m2之间时,每单位BMI降低后患者的GAgP风险增加18%  (adjusted OR = 0.82, 95%CI: 0.69, 0.97)。当BMI在22至28 kg/m2之间时,每单位BMI增加后患者的WBC计数增加1.12×109 /L (adjusted β = 0.12, 95%CI: 0.01, 0.23),而当BMI在22至18 kg/m2之间时,每单位BMI减少后患者的WBC计数增加0.2×109 /L (adjusted β = -0.2, 95%CI: -0.35, -0.04)。

结论:在中国36岁以下并且BMI值在18至28 kg/m2之间的GAgP患者中,BMI和GAgP风险, AL和WBC计数之间存在U型关系。GAgP最低比值比以及最低WBC计数的最佳BMI值为22 kg/m2。

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    2019-05-04 feather89
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    2018-07-24 sunyl07
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    2018-07-23 大爰

    学习了谢谢分享!!

    0

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