Gastroenterology:水果蔬菜摄入降低结直肠癌的风险获新证

2011-09-06 MedSci原创 MedSci原创

 近期,英国学者Dagfinn Aune等所进行的一项针对前瞻性研究的荟萃分析显示,水果、蔬菜摄入与结直肠癌风险呈现弱的、但统计学上有显著性的逆向相关性。相关报道发表于《胃肠病学》(Gastroenterology)杂志。   水果、蔬菜的摄入与结直肠癌的风险之间的关系曾被多项研究分析过,但仍因其结果的不一致性和所观察到的联系的不牢固性而具有争议。在该研究中,Dagfinn Aune等汇总了分类

 近期,英国学者Dagfinn Aune等所进行的一项针对前瞻性研究的荟萃分析显示,水果、蔬菜摄入与结直肠癌风险呈现弱的、但统计学上有显著性的逆向相关性。相关报道发表于《胃肠病学》(Gastroenterology)杂志。

  水果、蔬菜的摄入与结直肠癌的风险之间的关系曾被多项研究分析过,但仍因其结果的不一致性和所观察到的联系的不牢固性而具有争议。在该研究中,Dagfinn Aune等汇总了分类、线性和非线性、剂量—反应荟萃分析的队列研究的多方证据,以说明相关性。

  研究人员检索了PubMed上发布的截止到2010年5月底之前的有关水果、蔬菜的摄入与结直肠癌的风险的研究;收集了19个报告相对风险估计和95%可信区间(CI)的、水果和蔬菜摄入相关性的结直肠癌的前瞻性研究;采用随机效应模型估算总体相对危险。

  总体相对危险,最高和最低摄入量的之比,在水果与蔬菜的结合分析中为0.92(95% CI:0.86~0.99),水果为0.90(95% CI:0.83~0.98),蔬菜为0.91(95% CI:0.86~0.96)(异质性P分别为0.24,0.05和0.54)。负向相关性似乎仅限于结肠癌。在线性—剂量反应分析中,仅蔬菜的摄入(100克/天)与结直肠癌危险性显著相关(总体相对危险=0.98;95% CI:0.97~0.99)。然而,显著的逆向相关性出现于水果(P非线性<0.001)与蔬菜(P非线性=0.001)的非线性模型。当摄入量从非常低的水平开始增加的时候,风险降低的幅度最大。分析之间的一致性较好,也不存在小的研究偏倚。

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    2012-05-28 许安
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