JAHA:恩格列净对2型糖尿病患者心肌血流储备的影响

2021-07-19 MedSci原创 MedSci原创

恩格列净并未改善伴有心血管高风险的2型糖尿病患者MFR。该研究并不支持用MFR的短期改善来解释结局试验中观察到的心血管事件减少情况。

钠-葡萄糖协同转运蛋白2抑制剂可减少因心力衰竭而住院和血管死亡的人数,尽管其潜在机制尚未明确。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,恩格列净对2型糖尿病患者心肌血流储备影响(SIMPLE试验)分析了恩格列净对心血管疾病高风险的2型糖尿病患者反映了微血管灌注-心肌血流储备(MFR)的影响。

研究人员将90名患者随机分配至25mg 恩格列净,每日一次或安慰剂治疗,持续13周。该研究的主要结局是第13周时的MFR变化,通过铷82正电子发射断层扫描/计算机断层扫描进行量化。该研究的次要结局是静息率-压力乘积调整后的MFR变化、静息和应激期间心肌血流的变化以及可逆的心脏缺血。

恩格列净治疗13周后PET/CT参数的平均变化

受试者平均基线MFR为2.21(95%CI为2.08-2.35)。在恩格列净组为0.01(95%CI为-0.18至0.21),安慰剂组为0.06(95%CI为-0.15至0.27),第13周MFR与基线相比没有变化,没有治疗效果,为-0.05(95%CI为-0.33至0.23)。研究人员未观察到铷82正电子发射断层扫描/计算机断层扫描对次要结局参数存在影响。恩格列净治疗使糖化血红蛋白(A1c)降低0.76%(95%CI为1.0-0.5;P<0.001),血细胞比容增加1.69%(95%CI为0.7-2.6;P<0.001)。

由此可见,恩格列净并未改善伴有心血管高风险的2型糖尿病患者MFR。该研究并不支持用MFR的短期改善来解释结局试验中观察到的心血管事件减少情况。

原始出处:

Mikkel Jürgens.et al.Effects of Empagliflozin on Myocardial Flow Reserve in Patients With Type 2 Diabetes Mellitus: The SIMPLE Trial.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.020418

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1268584, encodeId=58b11268584cf, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383703, encodeId=dea01383e03b3, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475105, encodeId=134814e510541, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043697, encodeId=6927104369e9c, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 19 23:25:45 CST 2021, time=2021-07-19, status=1, ipAttribution=)]
    2021-07-21 zhaohui6731
  2. [GetPortalCommentsPageByObjectIdResponse(id=1268584, encodeId=58b11268584cf, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383703, encodeId=dea01383e03b3, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475105, encodeId=134814e510541, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043697, encodeId=6927104369e9c, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 19 23:25:45 CST 2021, time=2021-07-19, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1268584, encodeId=58b11268584cf, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383703, encodeId=dea01383e03b3, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475105, encodeId=134814e510541, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043697, encodeId=6927104369e9c, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 19 23:25:45 CST 2021, time=2021-07-19, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1268584, encodeId=58b11268584cf, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383703, encodeId=dea01383e03b3, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475105, encodeId=134814e510541, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 21 11:25:45 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043697, encodeId=6927104369e9c, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 19 23:25:45 CST 2021, time=2021-07-19, status=1, ipAttribution=)]
    2021-07-19 misszhang

    谢谢MedSci提供最新的资讯

    0

相关资讯

J Periodontol:牙周清创后辅助使用ω-3和ASA有益于治疗2型糖尿病患者的牙周炎

补充ω-3多不饱和脂肪酸(ω-3 PUFA)和低剂量阿司匹林(ASA)已被提议作为控制慢性炎症性疾病的宿主调节方案。本研究旨在调查口服ω-3 PUFA和ASA作为牙

HBP:机器学习使用高阶功能连接可以区伴有或不伴有认知障碍的2型糖尿病与健康人群

跨大规模脑内网络的dFC存在鉴别同步性,可以将T2DM-CI(和T2DM-noCI)与HC区分开来。

JCEM:2型糖尿病与总髋骨面积和骨密度变化的关系

与非T2DM患者相比,新发T2DM患者全髋骨面积的扩张程度较低。

Nutrients:纯素饮食对预防和治疗2型糖尿病有用吗?

纯素饮食可能被认为是西方饮食的可接受的安全替代品,并且与其他推荐的健康饮食模式(例如素食、地中海、阻止高血压的饮食方法(DASH)等)相当。

Diabetes Care:血清镁与2型糖尿病患者心衰、房颤和微血管并发症呈负相关

血清Mg2+浓度与HF和AF的风险以及CKD、糖尿病视网膜病变和T2D足部并发症的发生呈负相关。血糖控制部分介导了血清Mg2+与HF和微血管并发症之间的关联。

BMC Oral Health:牙周炎和2型糖尿病之间的流行病学关系

糖尿病(DM)是一种常见的代谢性疾病,由胰岛素分泌缺陷、胰岛素作用缺陷或两者的结合导致。牙周炎被定义为DM的第六种并发症,这意味着DM可以促进牙周炎的进展。大量随机对照试验(RCTs)显示牙周治疗可以