Diabetes Care:2型糖尿病患者SGLT2抑制剂与视网膜静脉阻塞风险的关系

2021-07-27 MedSci原创 MedSci原创

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究使用来自韩国国家健康保险服务的数据旨在评估钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂的使用与视网膜静脉阻塞(RVO)之间

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究使用来自韩国国家健康保险服务的数据旨在评估钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂的使用与视网膜静脉阻塞(RVO)之间的关联。


 
研究人员使用了2014年至2017年的全国数据,基于1:1的倾向得分匹配,纳入了47369名SGLT2抑制剂新用户和47369名其他降糖药物用户(oGLD)。在匹配的样本中,研究人员使用Cox比例风险模型来估计发生RVO的风险比(HR)和95%CI。基于主要结局,研究人员进行了探索性亚组分析。

在2.57年的随访期间,接受SGLT2抑制剂和oGLD治疗的患者RVO发生率分别为每1000人每年2.19人和1.79人。与使用oGLD治疗相比,新使用SGLT2抑制剂与RVO风险增加相关(HR为1.264[95%CI为1.056,1.513])。

生存曲线

在亚组分析中,研究人员观察到年龄和估计肾小球滤过率(eGFR)与SGLT2抑制剂之间存在显著的相互作用;60岁以上和eGFR<60mL/min/1.73m2的患者RVO的HR高于其他患者。
 
在匹配队列研究中,研究人员发现SGLT2抑制剂与RVO风险显著增加相关。伴有慢性肾病的老年患者发生RVO的风险更高
 
原始出处:
 
Min-Kyung Lee,et al.Sodium–Glucose Cotransporter 2 Inhibitors and Risk of Retinal Vein Occlusion Among Patients With Type 2 Diabetes: A Propensity Score–Matched Cohort Study.Diabetes care.2021.https://doi.org/10.2337/dc20-3133

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createdName=liuquan, createdTime=Wed Dec 29 04:39:02 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902592, encodeId=686619025929a, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Oct 07 00:39:02 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820472, encodeId=224a18204e2ef, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, 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  5. [GetPortalCommentsPageByObjectIdResponse(id=1852717, encodeId=36c91852e17b0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed May 11 00:39:02 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995638, encodeId=af76199563874, content=<a href='/topic/show?id=992411149e' target=_blank style='color:#2F92EE;'>#2抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1114, encryptionId=992411149e, topicName=2抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28b7142, 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href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue Sep 28 16:39:02 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639821, encodeId=36d916398216d, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Apr 25 18:39:02 CST 2022, time=2022-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761642, encodeId=81fa1e61642a8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Jul 08 02:39:02 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696980, encodeId=ef4f169698033, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Wed Jun 22 09:39:02 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270283, encodeId=0eda12e02834f, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Jul 29 10:39:02 CST 2021, time=2021-07-29, status=1, ipAttribution=)]
    2022-01-23 tulenzi
  6. [GetPortalCommentsPageByObjectIdResponse(id=1852717, encodeId=36c91852e17b0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed May 11 00:39:02 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995638, encodeId=af76199563874, content=<a href='/topic/show?id=992411149e' target=_blank style='color:#2F92EE;'>#2抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1114, encryptionId=992411149e, topicName=2抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28b7142, 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time=2022-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761642, encodeId=81fa1e61642a8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Jul 08 02:39:02 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696980, encodeId=ef4f169698033, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Wed Jun 22 09:39:02 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270283, encodeId=0eda12e02834f, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Jul 29 10:39:02 CST 2021, time=2021-07-29, status=1, ipAttribution=)]
    2021-09-28 fusion
  7. 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  9. 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    2022-06-22 tomyang96
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    2021-07-29 zutt

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跨大规模脑内网络的dFC存在鉴别同步性,可以将T2DM-CI(和T2DM-noCI)与HC区分开来。

BMC Oral Health:牙周炎和2型糖尿病之间的流行病学关系

糖尿病(DM)是一种常见的代谢性疾病,由胰岛素分泌缺陷、胰岛素作用缺陷或两者的结合导致。牙周炎被定义为DM的第六种并发症,这意味着DM可以促进牙周炎的进展。大量随机对照试验(RCTs)显示牙周治疗可以

Cardiovasc Diabetol:钠糖共转运体抑制剂可显著降低T2DM患者的心血管事件风险

启用SGLT-2i与T2DM患者较低的死亡率及心衰和CKD风险相关

JAHA:恩格列净对2型糖尿病患者心肌血流储备的影响

恩格列净并未改善伴有心血管高风险的2型糖尿病患者MFR。该研究并不支持用MFR的短期改善来解释结局试验中观察到的心血管事件减少情况。