NEJM:自闭症谱系障碍儿童和青少年鼻内催产素治疗疗效

2021-10-14 MedSci原创 MedSci原创

这项对自闭症谱系障碍的儿童和青少年进行鼻内催产素治疗的安慰剂对照试验显示,在24周的时间里,社会或认知功能指标的最小二乘平均变化与基线相比没有显著的组间差异。

实验研究和小型临床试验表明,鼻内催产素治疗可以减少自闭症谱系障碍患者的社交障碍。催产素已在临床实践中用于许多患有自闭症谱系障碍的儿童

近日,顶级医学期刊NEJM上发表了一篇研究文章,研究人员对患有自闭症谱系障碍的3至17岁儿童和青少年进行了一项为期24周、安慰剂对照的鼻内催产素治疗的2期试验。

参与者以1:1的比例随机分配,根据年龄和语言流畅程度进行分层,接受催产素或安慰剂,鼻内给药,总目标剂量为每天48国际单位。该研究的主要结局是异常行为清单修正社交退缩量表(ABC-mSW)从基线的最小二乘平均变化,其中包括13个条目(分数范围从0到39,分数越高表示社交互动越少)。该研究的次要结局包括两项额外的社会功能指标和一项简短的IQ指标。

在接受筛查的355名儿童和青少年中,有290名被纳入研究。总共有146名参与者被分配到催产素组,144名参与者被分配到安慰剂组;分别有139名和138名参与者完成了基线和至少一项基线后ABC-mSW评估,并被纳入改良的意向治疗分析。ABC-mSW评分(主要结局)相对于基线的最小二乘平均变化在催产素组为-3.7,在安慰剂组为-3.5(最小二乘均差为-0.2;95%置信区间为-1.5至1.0;P=0.61)。次要结局在试验组之间通常没有差异。两组不良事件的发生率和严重程度相似。

由此可见,这项对自闭症谱系障碍的儿童和青少年进行鼻内催产素治疗的安慰剂对照试验显示,在24周的时间里,社会或认知功能指标的最小二乘平均变化与基线相比没有显著的组间差异。

原始出处:
 
Linmarie Sikich,et al.Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder.NEJM.2021.https://www.nejm.org/doi/full/10.1056/NEJMoa2103583

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1937530, encodeId=e6b3193e530b7, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Nov 03 14:02:01 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063574, encodeId=daa310635e41a, content=自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dea5624354, createdName=ms7000000652321620, createdTime=Sun Oct 24 21:22:21 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313133, encodeId=659e1313133ea, content=<a href='/topic/show?id=454286386a1' target=_blank style='color:#2F92EE;'>#自闭症谱系障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86386, encryptionId=454286386a1, topicName=自闭症谱系障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec25412, createdName=yangpeizhi, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527807, encodeId=7e91152e80792, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529950, encodeId=43c1152995045, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060386, encodeId=5a1310603861f, content=哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:53:37 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060369, encodeId=f0591060369fe, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:33:42 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060342, encodeId=9f9810603424a, content=应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Thu Oct 14 09:10:18 CST 2021, time=2021-10-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1937530, encodeId=e6b3193e530b7, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Nov 03 14:02:01 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063574, encodeId=daa310635e41a, content=自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dea5624354, createdName=ms7000000652321620, createdTime=Sun Oct 24 21:22:21 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313133, encodeId=659e1313133ea, content=<a href='/topic/show?id=454286386a1' target=_blank style='color:#2F92EE;'>#自闭症谱系障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86386, encryptionId=454286386a1, topicName=自闭症谱系障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec25412, createdName=yangpeizhi, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527807, encodeId=7e91152e80792, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529950, encodeId=43c1152995045, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060386, encodeId=5a1310603861f, content=哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:53:37 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060369, encodeId=f0591060369fe, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:33:42 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060342, encodeId=9f9810603424a, content=应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Thu Oct 14 09:10:18 CST 2021, time=2021-10-14, status=1, ipAttribution=)]
    2021-10-24 ms7000000652321620

    自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1937530, encodeId=e6b3193e530b7, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Nov 03 14:02:01 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063574, encodeId=daa310635e41a, content=自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dea5624354, createdName=ms7000000652321620, createdTime=Sun Oct 24 21:22:21 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313133, encodeId=659e1313133ea, content=<a href='/topic/show?id=454286386a1' target=_blank style='color:#2F92EE;'>#自闭症谱系障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86386, encryptionId=454286386a1, topicName=自闭症谱系障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec25412, createdName=yangpeizhi, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527807, encodeId=7e91152e80792, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529950, encodeId=43c1152995045, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060386, encodeId=5a1310603861f, content=哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:53:37 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060369, encodeId=f0591060369fe, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:33:42 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060342, encodeId=9f9810603424a, content=应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Thu Oct 14 09:10:18 CST 2021, time=2021-10-14, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1937530, encodeId=e6b3193e530b7, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Nov 03 14:02:01 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063574, encodeId=daa310635e41a, content=自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dea5624354, createdName=ms7000000652321620, createdTime=Sun Oct 24 21:22:21 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313133, encodeId=659e1313133ea, content=<a href='/topic/show?id=454286386a1' target=_blank style='color:#2F92EE;'>#自闭症谱系障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86386, encryptionId=454286386a1, topicName=自闭症谱系障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec25412, createdName=yangpeizhi, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527807, encodeId=7e91152e80792, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529950, encodeId=43c1152995045, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060386, encodeId=5a1310603861f, content=哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:53:37 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060369, encodeId=f0591060369fe, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:33:42 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060342, encodeId=9f9810603424a, content=应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Thu Oct 14 09:10:18 CST 2021, time=2021-10-14, status=1, ipAttribution=)]
    2021-10-15 xiongke014
  5. [GetPortalCommentsPageByObjectIdResponse(id=1937530, encodeId=e6b3193e530b7, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Nov 03 14:02:01 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063574, encodeId=daa310635e41a, content=自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dea5624354, createdName=ms7000000652321620, createdTime=Sun Oct 24 21:22:21 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313133, encodeId=659e1313133ea, content=<a href='/topic/show?id=454286386a1' target=_blank style='color:#2F92EE;'>#自闭症谱系障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86386, encryptionId=454286386a1, topicName=自闭症谱系障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec25412, createdName=yangpeizhi, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527807, encodeId=7e91152e80792, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529950, encodeId=43c1152995045, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060386, encodeId=5a1310603861f, content=哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:53:37 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060369, encodeId=f0591060369fe, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:33:42 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060342, encodeId=9f9810603424a, content=应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Thu Oct 14 09:10:18 CST 2021, time=2021-10-14, status=1, ipAttribution=)]
    2021-10-15 zhanfl
  6. [GetPortalCommentsPageByObjectIdResponse(id=1937530, encodeId=e6b3193e530b7, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Nov 03 14:02:01 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063574, encodeId=daa310635e41a, content=自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dea5624354, createdName=ms7000000652321620, createdTime=Sun Oct 24 21:22:21 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313133, encodeId=659e1313133ea, content=<a href='/topic/show?id=454286386a1' target=_blank style='color:#2F92EE;'>#自闭症谱系障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86386, encryptionId=454286386a1, topicName=自闭症谱系障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec25412, createdName=yangpeizhi, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527807, encodeId=7e91152e80792, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529950, encodeId=43c1152995045, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060386, encodeId=5a1310603861f, content=哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:53:37 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060369, encodeId=f0591060369fe, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:33:42 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060342, encodeId=9f9810603424a, content=应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Thu Oct 14 09:10:18 CST 2021, time=2021-10-14, status=1, ipAttribution=)]
    2021-10-14 MYR哈哈哈哈

    哈哈哈

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1937530, encodeId=e6b3193e530b7, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Nov 03 14:02:01 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063574, encodeId=daa310635e41a, content=自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dea5624354, createdName=ms7000000652321620, createdTime=Sun Oct 24 21:22:21 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313133, encodeId=659e1313133ea, content=<a href='/topic/show?id=454286386a1' target=_blank style='color:#2F92EE;'>#自闭症谱系障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86386, encryptionId=454286386a1, topicName=自闭症谱系障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec25412, createdName=yangpeizhi, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527807, encodeId=7e91152e80792, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529950, encodeId=43c1152995045, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060386, encodeId=5a1310603861f, content=哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:53:37 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060369, encodeId=f0591060369fe, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:33:42 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060342, encodeId=9f9810603424a, content=应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Thu Oct 14 09:10:18 CST 2021, time=2021-10-14, status=1, ipAttribution=)]
    2021-10-14 MYR哈哈哈哈

    哈哈

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1937530, encodeId=e6b3193e530b7, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Nov 03 14:02:01 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063574, encodeId=daa310635e41a, content=自闭症谱系药物的试验,目前问题很多。相同的药物时不时的得出南辕北辙的结论。 我想目前当务之急有可能是对自闭症谱系做症状或者基因层面的细分,还得考虑患者年龄等环境情况。在细分后有些药物试验才有基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dea5624354, createdName=ms7000000652321620, createdTime=Sun Oct 24 21:22:21 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313133, encodeId=659e1313133ea, content=<a href='/topic/show?id=454286386a1' target=_blank style='color:#2F92EE;'>#自闭症谱系障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86386, encryptionId=454286386a1, topicName=自闭症谱系障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec25412, createdName=yangpeizhi, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527807, encodeId=7e91152e80792, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529950, encodeId=43c1152995045, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Fri Oct 15 23:02:01 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060386, encodeId=5a1310603861f, content=哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:53:37 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060369, encodeId=f0591060369fe, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=73be5472067, createdName=MYR哈哈哈哈, createdTime=Thu Oct 14 10:33:42 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060342, encodeId=9f9810603424a, content=应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Thu Oct 14 09:10:18 CST 2021, time=2021-10-14, status=1, ipAttribution=)]
    2021-10-14 病毒猎手

    应该再看亚人群,在6岁以内可能是有效的。年龄大了,效果可能不好了。对于幼年儿童,仍然可以再进行试验

    0

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