JAHA:成人与糖尿病相关的全因和心血管死亡率分析

2019-02-20 xing.T 网络

由此可见,糖尿病仍然与全因和心血管疾病死亡率显著相关,尽管糖尿病相关的过量死亡率在当代比以前更低。研究人员观察到死亡风险梯度随着HbA1c从6%增加到6.9%,表明即使不能推断出因果关系,HbA1c仍然是患者结局的预测因素。

糖尿病血管疾病(CVD)的危险因素,并且死亡率升高2至4倍。在当代CVD风险降低期间,美国接受常规治疗的患者尚未重新评估糖尿病相关死亡率。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员回顾性地分析了2002年至2014年期间在美国退伍军人事务保健系统接受治疗的963648名成年人; 平均随访时间为8年。研究人员使用协变量校正的发病率和多变量Cox比例风险回归评估糖尿病状态和血红蛋白A1c(HbA1c)与全因和CVD死亡率的关联。

在参与者中,34%患有糖尿病。与非糖尿病患者相比,糖尿病患者的全因死亡率和CVD死亡率分别为7.0(95%CI为6.7-7.4)和3.5(95%CI为3.3-3.7)死亡/1000人次每年。糖尿病相关死亡率的年龄、性别、人种和民族调整风险比为1.29(95%CI为1.28-1.31),并且随着CVD危险因素(风险比为1.18 [95%CI为1.16-1.19])和血糖(风险比为1.03 [95%CI为1.02-1.05])的调整而下降。在患有糖尿病的个体中,CVD死亡率随着HbA1c超过7%而增加(相对于HbA1c为6%-6.9%,HbA1c为7%-7.9%、8%-8.9%和≥9%的风险比分别为1.11 [95%CI为1.08-1.14]、1.25 [95%CI为1.22-1.29]和1.52 [95%CI为1.48-1.56] )。无论CVD病史或年龄如何,HbA1c为6%-6.9%与最低死亡率风险相关。

由此可见,糖尿病仍然与全因和心血管疾病死亡率显著相关,尽管糖尿病相关的过量死亡率在当代比以前更低。研究人员观察到死亡风险梯度随着HbA1c从6%增加到6.9%,表明即使不能推断出因果关系,HbA1c仍然是患者结局的预测因素。

原始出处:

Sridharan Raghavan.et al.Diabetes Mellitus–Related All‐Cause and Cardiovascular Mortality in a National Cohort of Adults.JAHA.2019.https://www.ahajournals.org/doi/full/10.1161/JAHA.118.011295

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