BMC Oral Health:牙周炎和2型糖尿病之间的流行病学关系

2021-07-08 MedSci原创 MedSci原创

糖尿病(DM)是一种常见的代谢性疾病,由胰岛素分泌缺陷、胰岛素作用缺陷或两者的结合导致。牙周炎被定义为DM的第六种并发症,这意味着DM可以促进牙周炎的进展。大量随机对照试验(RCTs)显示牙周治疗可以

糖尿病(DM)是一种常见的代谢性疾病,由胰岛素分泌缺陷、胰岛素作用缺陷或两者的结合导致。牙周炎被定义为DM的第六种并发症,这意味着DM可以促进牙周炎的进展。大量随机对照试验(RCTs)显示牙周治疗可以改善血糖控制。然而,关于牙周治疗是否对T2DM患者的糖化血红蛋白(HbA1c)有影响,两项大规模RCTs获得了相互矛盾的结果。本文中,研究人员总结了观察性研究的证据来探讨这种双向关系,旨在系统地回顾牙周炎和2型糖尿病(T2DM)之间的流行病学关系,研究结果已发表于BMC Oral Health。

研究人员检索了四个电子数据库,直到2018年12月。人工检索包括纳入研究的参考文献清单和相关期刊。评估T2DM和牙周炎之间关系的观察性研究被纳入。使用STATA进行了Meta分析。

 

结果,共纳入53项观察性研究。校正后的T2DM患病率在牙周炎患者中明显较高(OR = 4.04, p = 0.000),反之亦然(OR = 1.58, p = 0.000)。T2DM患者的牙周状况明显较差,反映在牙周袋深0.61 mm,附着丧失多0.89 mm,以及比没有T2DM的患者多丧失约2颗牙齿(所有P = 0.000)。队列研究的结果发现,T2DM可使患牙周炎的风险升高34%(P = 0.002)。T2DM患者的血糖控制可能导致不同的牙周炎结果。严重的牙周炎使T2DM的发生率增加53%(p = 0.000),而且这一结果是稳定的。相比之下,轻度牙周炎对T2DM发病率的影响(RR=1.28,P=0.007)不太稳定。

综上,T2DM和牙周炎之间存在着明显的双向关系。需要精心设计的队列研究来进一步证实这一发现。该结果表明,牙医和内科医生都需要意识到牙周炎和T2DM之间的紧密联系。

 

原始出处:

 

Chen-Zhou Wu, et al., Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health. 2020 Jul 11;20(1):204. doi: 10.1186/s12903-020-01180-w. 

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    2022-06-17 shizhenshan
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    2021-10-06 小几洁
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    2021-07-10 xugumin
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    2021-07-09 土豆你个马铃薯

    猛于虎提提

    0

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    2021-07-08 misszhang

    谢谢MedSci提供最新的资讯

    0

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