文献解读:交联透明质酸钠凝胶联合非剥脱性点阵激光用于皮肤年轻化治疗的有效性与安全性 !

2021-09-16 高德美 高德美

随着年龄的增长,我们的皮肤会逐渐老化,变得松弛、暗沉,这些变化主要与真皮层细胞(特别是成纤维细胞)再生细胞外基质的合成能力下降有关。此外,表皮层变薄和基底膜扁平化也是导致皮肤老化的原因。皮肤光老化后,

随着年龄的增长,我们的皮肤会逐渐老化,变得松弛、暗沉,这些变化主要与真皮层细胞(特别是成纤维细胞)再生细胞外基质的合成能力下降有关。此外,表皮层变薄和基底膜扁平化也是导致皮肤老化的原因。皮肤光老化后,主要的治疗目标应是改善肤色与肤质、增加皮肤紧致度以及减少皱纹。临床上主要的治疗方法包括填充剂注射、肉毒毒素注射、美塑疗法、激光、射频和强脉冲光(IPL)治疗。在皮肤年轻化治疗中,与单一疗法相比,联合治疗往往能取得更好的效果

Adriana Ribé,et al. 发表在《J Cosmet Laser Ther》期刊上的一项研究证实了透明质酸钠注射联合激光用于皮肤年轻化治疗的良好效果[1]。该研究共纳入9名女性患者,年龄42-62岁,皮肤光分型Ⅱ-Ⅳ级,均出现光老化现象(轻中度皱纹、轻中度皮肤松弛和日光性着色斑)。给予患者真皮深层注射交联透明质酸钠凝胶瑞蓝·唯瑅™,随后采用Affirm™激光照射治疗,每2-4周重复治疗一次,共4个疗程。研究者分别于治疗前、治疗后一个月及治疗4个疗程后对治疗区域进行拍照和活检以评估疗效。患者在第2和第4次治疗后采用总体美观改善量表(0:差;1:无变化;2:改善;3:明显改善;4:极大改善)进行自我评估。

研究结果显示:与治疗前相比,接受瑞蓝·唯瑅™联合Affirm™激光治疗后,治疗区域皮肤的外观和肤色变得更加均匀,色素斑显著减少,且皮肤变得更有光泽。同时观察到皮肤细纹(中度),皮肤质地和皮肤紧致度(轻中度)也有所改善。第2、4次治疗后,总体美观改善量表评估结果显示,所有患者都认为自己的皮肤状况得到改善,其中,67%(6例)的患者认为得到明显改善,22%(2例)得到一般改善,11%(1例)得到极大改善(见图1)。

图1. 总体美观改善量表评分患者比例

 

此外,对皮肤组织活检后发现,接受瑞蓝·唯瑅™联合激光治疗后,患者的皮肤细胞结构、皮肤中的胶原蛋白和弹性纤维也均得到了改善。与治疗前相比,治疗后的皮肤更富营养化,较治疗前具有更多的角质细胞层和更好的角质形成细胞极性。

研究还观察到,在联合治疗前,皮肤乳头状真皮层中原有的疏松和致密的网状结构(主要是III型胶原蛋白)已部分丧失,取而代之的是致密的纤维化外观(图2A)。瑞蓝·唯瑅™联合激光治疗4个疗程后,可立刻在乳头状真皮层上观察到具有精细编织网和疏松状外观的胶原蛋白,同时观察到胶原纤维的数量和厚度增加。与立刻治疗后相比,治疗后1个月观察到了相似的结果(图2B)。

图2 皮肤活检后的胶原蛋白染色

(A)治疗前;(B)治疗后1个月。绿色为胶原蛋白。

(A)中黄色箭头指向的胶原纤维短而细(B)中胶原纤维数量增多,厚度增加

 

研究中唯一观察到的不良事件为水疱形成,于2周内恢复,未残留疤痕。

瑞蓝·唯瑅™是一种注射用交联透明质酸钠凝胶可通过刺激细胞外基质(ECM)改善皮肤衰老现象,使肌肤快速恢复活力[2,3]。其效果源于交联透明质酸结合水的能力[4]。透明质酸(HA)是稳定ECM的重要成分,可结合大量水,且在水合稳态中起重要作用。HA不仅是重要的组织结构成分,还具有一定功能性,与细胞外物质输送(组织中电解质、营养物质和分解产物的扩散)和免疫系统活性有着密切关系[5]。

瑞蓝·唯瑅™适用于需要改善皮肤外观的人群,对于紫外线受损严重的皮肤,联合治疗或许是更优的选择。激光治疗是针对紫外线受损皮肤的有效治疗方案,有研究者推荐,在激光治疗前行交联透明质酸注射可以提高皮肤对激光热刺激的反应性,从而获得更好的治疗效果[5]。

Adriana Ribé,et al.研究结果也证实,对比单纯的激光治疗,激光治疗前行瑞蓝·唯瑅™注射可使肌肤更快恢复水润和弹性。该研究还发现,激光主要作用于皮肤表皮层和浅表真皮层,而瑞蓝·唯瑅™主要作用与中-深层的真皮层,将两者结合,皮肤全层均可得到有效改善。

 

以上案例说明,瑞蓝·唯瑅™联合激光治疗可有效实现肌肤年轻化,减少皱纹,提升肌肤紧致度,改善肤色和肤质,为皮肤年轻化治疗提供了有效方案。

 

CN/VIT/0126/0720b

材料仅供医疗卫生专业人士学习交流

不作为临床使用推荐及其他用途

相关临床应用应符合中国国家药品监督管理局批准的使用说明书

https://pubmed.ncbi.nlm.nih.gov/21699363/

注册高德美院医师社区

获得更多医美前沿资讯,点击下方链接即可跳转

http://ypxcx.medsci.cn/calderma/index.html#/

 

参考文献:

1. Ribé A, Ribé N. Neck skin rejuvenation: histological and clinical changes after combined therapy with a fractional non-ablative laser and stabilized hyaluronic acid-based gel of non-animal origin. J Cosmet Laser Ther. 2011;13(4):154-161.

2. Carruthers JD, Carruthers JA, Humphrey S. Fillers and neocollagenesis. Dermatol Surg. 2014;40 Suppl 12:S134-S136.

3. Wang F, Garza LA, Kang S, et al. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol. 2007;143(2):155-163.

4. Restylane Vital 说明书

5. Kerscher, Martina & Buntrock, Heike & Hund, Martina & Mokosch, Anna & Ogilvie, Alexandra & Samimi-Fard, Shirin & Waibel, Maja. (2017). Restylane® Skinboosters™ for the improvement of the skin quality - Results of a consensus meeting. Cosmetic Medicine. Cosmetic Medicine.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1276746, encodeId=ad5212e6746d8, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279792, encodeId=78cb12e97925a, content=<a href='/topic/show?id=265c66e50ea' target=_blank style='color:#2F92EE;'>#激光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461081, encodeId=663b14610817f, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052223, encodeId=47461052223d0, content=发他就不会不好咯哭呢糊涂, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Sep 17 08:42:10 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052184, encodeId=859d105218490, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee662910810, createdName=刘明国, createdTime=Fri Sep 17 05:46:21 CST 2021, time=2021-09-17, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1276746, encodeId=ad5212e6746d8, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279792, encodeId=78cb12e97925a, content=<a href='/topic/show?id=265c66e50ea' target=_blank style='color:#2F92EE;'>#激光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461081, encodeId=663b14610817f, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052223, encodeId=47461052223d0, content=发他就不会不好咯哭呢糊涂, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Sep 17 08:42:10 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052184, encodeId=859d105218490, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee662910810, createdName=刘明国, createdTime=Fri Sep 17 05:46:21 CST 2021, time=2021-09-17, status=1, ipAttribution=)]
    2021-09-18 oliver169
  3. [GetPortalCommentsPageByObjectIdResponse(id=1276746, encodeId=ad5212e6746d8, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279792, encodeId=78cb12e97925a, content=<a href='/topic/show?id=265c66e50ea' target=_blank style='color:#2F92EE;'>#激光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461081, encodeId=663b14610817f, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052223, encodeId=47461052223d0, content=发他就不会不好咯哭呢糊涂, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Sep 17 08:42:10 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052184, encodeId=859d105218490, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee662910810, createdName=刘明国, createdTime=Fri Sep 17 05:46:21 CST 2021, time=2021-09-17, status=1, ipAttribution=)]
    2021-09-18 lishizhe
  4. [GetPortalCommentsPageByObjectIdResponse(id=1276746, encodeId=ad5212e6746d8, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279792, encodeId=78cb12e97925a, content=<a href='/topic/show?id=265c66e50ea' target=_blank style='color:#2F92EE;'>#激光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461081, encodeId=663b14610817f, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052223, encodeId=47461052223d0, content=发他就不会不好咯哭呢糊涂, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Sep 17 08:42:10 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052184, encodeId=859d105218490, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee662910810, createdName=刘明国, createdTime=Fri Sep 17 05:46:21 CST 2021, time=2021-09-17, status=1, ipAttribution=)]
    2021-09-17 查查佳佳

    发他就不会不好咯哭呢糊涂

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1276746, encodeId=ad5212e6746d8, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279792, encodeId=78cb12e97925a, content=<a href='/topic/show?id=265c66e50ea' target=_blank style='color:#2F92EE;'>#激光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461081, encodeId=663b14610817f, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sat Sep 18 02:32:14 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052223, encodeId=47461052223d0, content=发他就不会不好咯哭呢糊涂, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Sep 17 08:42:10 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052184, encodeId=859d105218490, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee662910810, createdName=刘明国, createdTime=Fri Sep 17 05:46:21 CST 2021, time=2021-09-17, status=1, ipAttribution=)]
    2021-09-17 刘明国

    学习

    0

相关资讯

国内首部《医学抗衰老行业规范化指南》发布

2016年1月23日,中国整形美容协会抗衰老分会在北京举办了《医学抗衰老行业规范化指南》新闻发布会,这是国内行业组织第一次公开发布相关规范化指导性文件。随着全球社会老龄化问题的愈发严重,医学抗衰老行业的发展前景十分广阔。但是,由于现代医学还不能准确回答人体衰老的机理,更不能提出一个系统科学的延缓衰老的解决办法,加之政府部门监管政策滞后和监管手段缺失,导致医学抗衰老行业乱象丛生。一些机构受高额利润的

3家上市,医美头部资产稀缺,企业寻求实在的业务增长和利润曲线

北京时间11月6月,透明质酸行业龙头华熙生物成功登陆科创板。2019年上半年,公司原料业务仍在主营业务中占比最大,整体规模维持稳定增长的态势,增幅为13.78%,各主要类型原料产品收入同比均有所上升。公司医疗终端产品业务得益于注射用修饰透明质酸钠凝胶产品收入的大幅提高,2019年1-6月医疗终端产品取得51.66%的同比收入增幅。

医美机构“流量思维” 割韭菜的骗子模式难以为继

郑州的孟明星大夫给我讲了一故事:10年前,他在火车站碰见过卖擦鞋剂的骗子,10元钱1瓶;10年后,还是那个火车站,骗子还在,还是那款擦鞋剂,换了个包装,改成200元2瓶;还是会有人上当。孟大夫觉得这个现象很有意思,我们详细讨论了一下这个案例。

恒大许家印成中国新首富 盘点32亿医疗布局

9月18日,恒大集团董事局主席许家印成为中国新首富。其在医疗领域的投资已达32亿元。

中国将打破医师执业证终生制 三大专业医师率先开展定期考核

    8月10日,第22届中国内镜医师大会在广东省中山市开幕,记者从卫生部内镜与微创医师定期考核专家委员会获悉,该委员会将首次启动全国医师终生定期统考制度,包括内镜微创、病理学、整形美容在内的三个专业将在全国率先开展定期考核。     近期在卫生部召开的“全国医师定期考核内镜与微创专业委员会成立暨第一次考试工作会议”上,内镜与微创医师