Clin Respir J:AR与NAR患者的血清瘦素差异及血清瘦素的诊断价值

2021-09-12 AlexYang MedSci原创

比较了过敏性鼻炎(AR)和非过敏性鼻炎(NAR)患者的血清瘦素水平,并评估了瘦素的诊断价值情况。

鼻炎即鼻腔内膜炎症,症状包括瘙痒、鼻出血及鼻塞。根据皮刺或血清特异性免疫球蛋白E(IgE)测试,结合症状表现,鼻炎可分为过敏性鼻炎(AR)和非过敏性鼻炎(NAR)。来自美国和欧洲的研究估计,7%-19%的成人患有NAR。

瘦素可能在气道炎症中存在关键作用。然而,很少有研究评估它在不同病因鼻炎中的作用

近期,来自土耳其的研究人员在《Clin Respir J》杂志上发表文章,比较了过敏性鼻炎(AR)和非过敏性鼻炎(NAR)患者的血清瘦素水平,并评估了瘦素的诊断价值情况

研究人员对慢性鼻炎患者进行了皮刺测试(ALK-Abello/Madrid)和血清特异性免疫球蛋白E测试(UniCAP 100-Pharmacia),并结合症状对患者进行了分类。

研究共招募了398名患者,平均年龄为29.03岁,分为AR和NAR两组。结果发现,无论有无哮喘,NAR和AR患者的平均血清瘦素水平相似,但两组中的女性患者血清瘦素水平明显高于男性。另外,在AR患者中,肥胖患者的瘦素水平明显高于非肥胖患者。在相关性分析中,瘦素水平与女性性别、较大年龄和高体重指数(BMI)有关。与NAR患者相比,尽管AR患者的鼻部症状总分(TNSS)更高,但瘦素水平与TNSS、症状的严重程度和季节性以及过敏原的致敏性没有关联。

AR组与NAR组的血清瘦素分析

在逻辑回归分析中,发现较小的年龄和高血清瘦素水平是诊断AR的独立预测因素

过敏性鼻炎风险因素分析

综上所述,高BMI的女性更容易患AR。另外,瘦素作为区分AR和NAR的诊断工具价值有限

原始出处:

Ayse Fusun Kalpaklıoglu , Ayşe Baccioglu , Sümeyra Alan Yalim et al. Does serum leptin levels differ between patients with rhinitis of allergic versus nonallergic aetiology? Clin Respir J. Aug 2021

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2075949, encodeId=693520e5949d3, content=<a href='/topic/show?id=7ad889426ce' target=_blank style='color:#2F92EE;'>#血清瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89426, encryptionId=7ad889426ce, topicName=血清瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri May 20 07:13:41 CST 2022, time=2022-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721696, encodeId=76911e21696ed, content=<a href='/topic/show?id=39d6915e9bf' target=_blank style='color:#2F92EE;'>#诊断价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91579, encryptionId=39d6915e9bf, topicName=诊断价值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c7d33065043, createdName=medscijoin, createdTime=Wed Jun 15 20:13:41 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366650, encodeId=5b161366650ff, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 14 03:13:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016839, encodeId=23d61016839b2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88df5570639, createdName=周峰, createdTime=Sun Sep 12 19:02:39 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016807, encodeId=ed5d101680e46, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809a5256377, createdName=147f1c78m80暂无昵称, createdTime=Sun Sep 12 16:00:51 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016770, encodeId=22c81016e7091, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210912/5a91a9ac998f4d23a8131323622aa282/5cb03d1c79354c5586f053ae29233b51.jpg, createdBy=6bde63220, createdName=alanta, createdTime=Sun Sep 12 15:05:04 CST 2021, time=2021-09-12, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2075949, encodeId=693520e5949d3, content=<a href='/topic/show?id=7ad889426ce' target=_blank style='color:#2F92EE;'>#血清瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89426, encryptionId=7ad889426ce, topicName=血清瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri May 20 07:13:41 CST 2022, time=2022-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721696, encodeId=76911e21696ed, content=<a href='/topic/show?id=39d6915e9bf' target=_blank style='color:#2F92EE;'>#诊断价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91579, encryptionId=39d6915e9bf, topicName=诊断价值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c7d33065043, createdName=medscijoin, createdTime=Wed Jun 15 20:13:41 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366650, encodeId=5b161366650ff, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 14 03:13:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016839, encodeId=23d61016839b2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88df5570639, createdName=周峰, createdTime=Sun Sep 12 19:02:39 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016807, encodeId=ed5d101680e46, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809a5256377, createdName=147f1c78m80暂无昵称, createdTime=Sun Sep 12 16:00:51 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016770, encodeId=22c81016e7091, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210912/5a91a9ac998f4d23a8131323622aa282/5cb03d1c79354c5586f053ae29233b51.jpg, createdBy=6bde63220, createdName=alanta, createdTime=Sun Sep 12 15:05:04 CST 2021, time=2021-09-12, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2075949, encodeId=693520e5949d3, content=<a href='/topic/show?id=7ad889426ce' target=_blank style='color:#2F92EE;'>#血清瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89426, encryptionId=7ad889426ce, topicName=血清瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri May 20 07:13:41 CST 2022, time=2022-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721696, encodeId=76911e21696ed, content=<a href='/topic/show?id=39d6915e9bf' target=_blank style='color:#2F92EE;'>#诊断价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91579, encryptionId=39d6915e9bf, topicName=诊断价值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c7d33065043, createdName=medscijoin, createdTime=Wed Jun 15 20:13:41 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366650, encodeId=5b161366650ff, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 14 03:13:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016839, encodeId=23d61016839b2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88df5570639, createdName=周峰, createdTime=Sun Sep 12 19:02:39 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016807, encodeId=ed5d101680e46, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809a5256377, createdName=147f1c78m80暂无昵称, createdTime=Sun Sep 12 16:00:51 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016770, encodeId=22c81016e7091, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210912/5a91a9ac998f4d23a8131323622aa282/5cb03d1c79354c5586f053ae29233b51.jpg, createdBy=6bde63220, createdName=alanta, createdTime=Sun Sep 12 15:05:04 CST 2021, time=2021-09-12, status=1, ipAttribution=)]
    2021-09-14 sodoo
  4. [GetPortalCommentsPageByObjectIdResponse(id=2075949, encodeId=693520e5949d3, content=<a href='/topic/show?id=7ad889426ce' target=_blank style='color:#2F92EE;'>#血清瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89426, encryptionId=7ad889426ce, topicName=血清瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri May 20 07:13:41 CST 2022, time=2022-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721696, encodeId=76911e21696ed, content=<a href='/topic/show?id=39d6915e9bf' target=_blank style='color:#2F92EE;'>#诊断价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91579, encryptionId=39d6915e9bf, topicName=诊断价值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c7d33065043, createdName=medscijoin, createdTime=Wed Jun 15 20:13:41 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366650, encodeId=5b161366650ff, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 14 03:13:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016839, encodeId=23d61016839b2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88df5570639, createdName=周峰, createdTime=Sun Sep 12 19:02:39 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016807, encodeId=ed5d101680e46, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809a5256377, createdName=147f1c78m80暂无昵称, createdTime=Sun Sep 12 16:00:51 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016770, encodeId=22c81016e7091, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210912/5a91a9ac998f4d23a8131323622aa282/5cb03d1c79354c5586f053ae29233b51.jpg, createdBy=6bde63220, createdName=alanta, createdTime=Sun Sep 12 15:05:04 CST 2021, time=2021-09-12, status=1, ipAttribution=)]
    2021-09-12 周峰

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2075949, encodeId=693520e5949d3, content=<a href='/topic/show?id=7ad889426ce' target=_blank style='color:#2F92EE;'>#血清瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89426, encryptionId=7ad889426ce, topicName=血清瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri May 20 07:13:41 CST 2022, time=2022-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721696, encodeId=76911e21696ed, content=<a href='/topic/show?id=39d6915e9bf' target=_blank style='color:#2F92EE;'>#诊断价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91579, encryptionId=39d6915e9bf, topicName=诊断价值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c7d33065043, createdName=medscijoin, createdTime=Wed Jun 15 20:13:41 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366650, encodeId=5b161366650ff, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 14 03:13:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016839, encodeId=23d61016839b2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88df5570639, createdName=周峰, createdTime=Sun Sep 12 19:02:39 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016807, encodeId=ed5d101680e46, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809a5256377, createdName=147f1c78m80暂无昵称, createdTime=Sun Sep 12 16:00:51 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016770, encodeId=22c81016e7091, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210912/5a91a9ac998f4d23a8131323622aa282/5cb03d1c79354c5586f053ae29233b51.jpg, createdBy=6bde63220, createdName=alanta, createdTime=Sun Sep 12 15:05:04 CST 2021, time=2021-09-12, status=1, ipAttribution=)]
    2021-09-12 147f1c78m80暂无昵称

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2075949, encodeId=693520e5949d3, content=<a href='/topic/show?id=7ad889426ce' target=_blank style='color:#2F92EE;'>#血清瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89426, encryptionId=7ad889426ce, topicName=血清瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri May 20 07:13:41 CST 2022, time=2022-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721696, encodeId=76911e21696ed, content=<a href='/topic/show?id=39d6915e9bf' target=_blank style='color:#2F92EE;'>#诊断价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91579, encryptionId=39d6915e9bf, topicName=诊断价值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c7d33065043, createdName=medscijoin, createdTime=Wed Jun 15 20:13:41 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366650, encodeId=5b161366650ff, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 14 03:13:41 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016839, encodeId=23d61016839b2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88df5570639, createdName=周峰, createdTime=Sun Sep 12 19:02:39 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016807, encodeId=ed5d101680e46, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809a5256377, createdName=147f1c78m80暂无昵称, createdTime=Sun Sep 12 16:00:51 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016770, encodeId=22c81016e7091, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210912/5a91a9ac998f4d23a8131323622aa282/5cb03d1c79354c5586f053ae29233b51.jpg, createdBy=6bde63220, createdName=alanta, createdTime=Sun Sep 12 15:05:04 CST 2021, time=2021-09-12, status=1, ipAttribution=)]
    2021-09-12 alanta

    学习了

    0

相关资讯

J Endod:瘦素对成牙本质分化和血管发生的作用:一项体内研究

瘦素作为一种肽类激素由脂肪组织分泌。这篇研究的目的是为了体内评估瘦素对修复性牙本质形成及血管再生的影响。

Hypertension:血浆瘦素水平和血压进展之间的关系

血浆瘦素浓度可能有助于识别高危人群,在未来的研究中可以将其作为高血压预防和治疗策略的靶点。

JCEM:孕中期瘦素和脂联素水平作为自闭症谱系障碍的预测因子

孕前BMI和妊娠期脂联素水平可能是监测自闭症风险的有效指标。产前脂联素水平升高可能在ASD预防中发挥者重要作用。

Nature:瘦素和能量平衡

瘦素(Leptin)是一种由脂肪组织分泌的激素,它在血清中的含量与动物脂肪组织大小成正比。瘦素作用于位于中枢神经系统的受体(Leptin Receptor) 从而调控生物的行为以及新陈代谢。

Nature:燃脂不积极,神经有问题?瘦素发现者团队《自然》全新发文

减肥是现代人越来越关注的一个话题。真正引燃体内储存脂肪的,是嵌入在脂肪组织中的一类神经。如果缺少合适的刺激,这些支配脂肪的神经会集体萎缩;相反,如果接收到正确的信号,神经展现出惊人的生长能力,促进燃脂

NATURE:神经和脂肪组织靠什么交流?

瘦素基因(ob)的突变会导致代谢紊乱,包括严重肥胖,以及产热和溶脂的缺陷,这两者都是由交感神经系统调节的脂肪组织功能。然而,至今为止,我们对于这些交感神经相关的异常的机制仍然不清楚。